Introduction: It is believed that uremia causes destruction of white blood cells (WBC) and thus causes leukopenia. Therefore this study had an attempt to assess the effect of uremia on WBC count.

Materials and Methods: This case control study was conducted on 120 uremic patients and 100 samples as control group. All samples were examined for determination of urea and creatinine in their serum and complete blood counts were determined.

Results and Conclusions: In healthy individuals, the mean value of urea was 14.5±1.9 mg/dL and the mean value of creatinine was 0.9±0.2 mg/dL (male) and 0.66±3.2 mg/dL (female). In the patient group, the mean value of urea was 83±2.4 mg/dL. The mean value of creatinin in male and female were 2.4±1.3 mg/dL and 2.1±1.7 mg/dL respectively. The mean of WBC count in case and control groups were 6.08± 2.24 and 6.17± 2.43x109/L respectively (p=0.71). Our results indicate that uremia cannot change leukocyte count.