Background and Aims: The immune system protects the body against many invasive foreign materials. The aim of this study was to investigate the effect of an intense anaerobic exercise session on serum IgG, IgM and IgA levels in handballists, volleybalists and climbers.

Materials and Methods: In this study, 45 professional athletes with the average age of 20-30 years who had participated in the major leagues and the first batch of Zahedan city were enrolled. To assess anaerobic power the 30 second Wingate test was used. Blood samples before, immediately after, and 2h after exercises were collected, and serum levels of immunoglobulins IgG, IgM and IgA were measured by nephelometry method.

Results: The results of this study indicated that the level of serum immunoglobulins IgG, IgM ˛ IgA concentration in all three study groups before and after and two hours past exercise did not show significant change (P>0.05).

Conclusions: Our findings showed that short anaerobic exercise does not have any effect on the level of immunoglobulins in athletes.