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International Journal of Medical Laboratory
Shahid Sadoughi University of Medical Sciences
Thu, Apr 25, 2024
[Archive]
Volume 2, Issue 2 (August 2015)
IJML 2015, 2(2): 81-86 |
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Hadinedoushan H, Dehghan-Manshadi M, Zare F. Determination of Hepatitis B Virus Genotypes in Yazd, Central Province of Iran. IJML 2015; 2 (2) :81-86
URL: http://ijml.ssu.ac.ir/article-1-51-en.html
URL: http://ijml.ssu.ac.ir/article-1-51-en.html
Immunology Department, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Immunology Department, Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract: (2778 Views)
Background and Aims: Hepatitis B virus (HBV) infects the liver and causes acute and chronic hepatitis, hepatocellular carcinoma and cirrhosis. HBV has been divided to eight genotypes (A–H) and subgenotypes of A, B, C and F. For the first time, we determined HBV genotypes in infected samples by INNO-LiPA method in Yazd, central province of Iran.
Materials and Methods: This study was performed on samples suspected of HBV infection. The sera of fifteen out of ninety-five samples that had shown positive results by RT-PCR were used for HBV genotyping by using INNO-LiPA HBV genotyping assay.
Results and Conclusions: Seven (46.7%) out of fifteen samples were female. The mean age of the patients was 37.8±14.3 years. The average number copy of HBV in infected samples was 1.04×106±4.74×105 Copies/ml. All fifteen infected samples had genotype D. Our results showed that HBV genotype D was the only detectable genotype in Yazd, central province of Iran. A further study with a larger sample size in different provinces of Iran is needed to identify HBV genotypes in Iran.
Materials and Methods: This study was performed on samples suspected of HBV infection. The sera of fifteen out of ninety-five samples that had shown positive results by RT-PCR were used for HBV genotyping by using INNO-LiPA HBV genotyping assay.
Results and Conclusions: Seven (46.7%) out of fifteen samples were female. The mean age of the patients was 37.8±14.3 years. The average number copy of HBV in infected samples was 1.04×106±4.74×105 Copies/ml. All fifteen infected samples had genotype D. Our results showed that HBV genotype D was the only detectable genotype in Yazd, central province of Iran. A further study with a larger sample size in different provinces of Iran is needed to identify HBV genotypes in Iran.
Type of Study: Research |
Subject:
General
Received: 2015/08/18 | Accepted: 2015/08/18 | Published: 2015/08/18
Received: 2015/08/18 | Accepted: 2015/08/18 | Published: 2015/08/18
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