Write your message
Volume 11, Issue 2 (May 2024)                   IJML 2024, 11(2): 101-116 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Tari K, Valizadeh Ardalan P, Abroun S. microRNAs in T-Cell Acute Lymphoblastic Leukemia: Roles and Contributions to Treatment Response. IJML 2024; 11 (2) :101-116
URL: http://ijml.ssu.ac.ir/article-1-534-en.html
microRNAs in T-Cell Acute Lymphoblastic Leukemia: Roles and Contributions to Treatment Response
Kaveh Tari , Pooya Valizadeh Ardalan , Saied Abroun *
Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Abstract:   (71 Views)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy induced by the proliferation of immature T-cell precursors. Even with the development of multi-agent chemotherapy, treatment failure, and relapse remain the most important challenges because of drug resistance. miRNAs are a class of small non-coding RNAs that modulate the expression of target mRNAs at the post-transcription level. They play significant roles in many biological processes, including tumorigenesis, differentiation, and apoptosis. Recent research has underlined the contribution of specific miRNAs to the pathogenesis of T-ALL and drug resistance. In the present review, the therapeutic potential of miRNA modulation in T-ALL disease will be discussed according to their role in disease biology, mechanisms of resistance, and possible strategies for clinical application.
Keywords: microRNAs, T-cell Acute Lymphoblastic Leukemia, Treatment Response
Full-Text [PDF 302 kb]   (43 Downloads) |   |   Full-Text (HTML)  (12 Views)  
Type of Study: Research | Subject: Immunology
Received: 2024/10/14 | Accepted: 2024/10/22 | Published: 2025/03/8
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | International Journal of Medical Laboratory

Designed & Developed by : Yektaweb