International Journal of Medical Laboratory

en Comparing the Effect of Saffron Aqueous Extract with Purslane on Cocaine-induced Locomotor Activity in Mice بیوشیمی Biochemistry پژوهشي Research <div style="text-align: justify;">Introduction: Cocaine can increase motor activity by activating the dopaminergic system. The aim of this study is investigating the effect of saffron and purslane extract on cocaine-induced motor activity in mice. Materials and Methods: 63 mice divide in 9 groups of 7. Group one was the control group and receive saline by intraperitoneal injection and their locomotor activity was measured. The second group received a medium dose of saffron, 150 mg/kg, and the third group received a medium dose of purslane, 50 mg/kg. The other 6 groups were first injected with cocaine at a dose of 10 mg/kg for 10 days. The motor activity of the mice was measured and the results were recorded. On the 10th day, after one hour of cocaine injection, groups 4, 5 and 6 were treated with saffron at doses of 50, 150 and 250 mg/kg respectively and groups 7, 8 and 9 were treated with purslane at doses of 20, 50 and 80 mg/kg respectively. Results: The injection of saffron and purslane extract alone in the second and third group mice caused a decrease in the motor activity of the mice compared to the first group. Injection of 10 mg/kg of cocaine in mice causes an increase in their motor activity. After the induction of addiction the injection of saffron and purslane extract caused a dose-dependent decrease in motor activity in mice. Conclusion: The findings show that the aqueous extract of saffron and purslane may play important role in reducing the symptoms of cocaine withdrawal and motor activity.</div> Cocaine, Mice, Motor activity, Purslane, Saffron 0 0 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-202-7&slc_lang=en&sid=1 Hamid Reza Jamshidi حمیدرضا جمشیدی hrz.jamshidi@gmail.com 0000-0002-2739-2847 Yes Department of Toxicology-Pharmacology, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Toxicology-Pharmacology, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mahdieh Kargar مهدیه کارگر hrz.jamshidii@gmail.com No School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran