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Volume 3, Issue 3 (August 2016)                   IJML 2016, 3(3): 150-158 | Back to browse issues page

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Moghimi B, Gharibi S, Farashahi Yazd E, Taher Tahoori M, Kalantar S M. Role of miR-146a in Immune System and Autoimmunity. IJML. 2016; 3 (3) :150-158
URL: http://ijml.ssu.ac.ir/article-1-125-en.html
Department of Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract:   (2280 Views)

MicroRNAs (miRNAs) are small preserved non-coding RNA molecules that regulate gene expression post-transcriptionally by targeting the 3' UTR of mRNAs for translational repression or degradation. The rising evidence has established the significant role of miRNAs within the regulation of immune system and the prevention of autoimmunity. MiR-146a has obtained an importance as a modulator of differentiation and the function of cells of the adaptive, as well as innate immunity rapidly. In this paper, we summarize the recent understanding of the role of miR-146a in adaptive and innate immune responses, as well as in autoimmunity.

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Type of Study: Research | Subject: Immunology
Received: 2016/11/2 | Accepted: 2016/11/2 | Published: 2016/11/2

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