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Volume 7, Issue 1 (February 2020)                   IJML 2020, 7(1): 41-48 | Back to browse issues page

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Ghorban K, Dadmanesh M, Sheikhfathollahi M, Rezai Z, Ezati P, Salmani M H, et al . IL-8 May Be the Target of Arsenic in Human Breast Milk. IJML. 2020; 7 (1) :41-48
URL: http://ijml.ssu.ac.ir/article-1-300-en.html
5Department of Food Hygiene and Safety, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract:   (849 Views)
Background and Aims: The critical aim of this study was to evaluate the effects of breast-milk contamination with Nickel and Arsenic, as well as aflatoxin M1 (AFM1) on the milk levels of IL-6 and IL-8. 
Materials and Methods: Breast milk was collected from 76 mothers on the 30th day post-parturition and milk levels of AFM1, Nickel, Arsenic, IL-6 and IL-8 were evaluated.
Results: The results showed 8 and 29 out of 76 collected samples being contaminated with AFM1, Nickel and Arsenic, respectively. Levels of IL-6 and IL-8 in the milk samples did not differ in AFM1 and Nickel and Arsenic contaminated milk compared with the normal controls (non-contaminated milks). There was a moderate positive relation between milk levels of IL-8 and Arsenic.
Conclusions: Although AFM1, Nickel and Arsenic are the inducers of cytokine production; they are unable to induce secretion of IL-6 in breast milk. Arsenic can be a trigger of IL-8, which is a strong chemoattract for neutrophils. Thus, it appears that Arsenic may induce an inflammation in milk in IL-8 dependent manner.
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Type of Study: Research | Subject: Immunology
Received: 2019/03/2 | Accepted: 2020/01/13 | Published: 2020/01/30

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