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International Journal of Medical Laboratory
Shahid Sadoughi University of Medical Sciences
Thu, Dec 26, 2024
[Archive]
Volume 10, Issue 3 (August 2023)
IJML 2023, 10(3): 254-263 |
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Fallah Raoufi M, Mokhlesabadi Farahani T, Sadat Mousavi Sadr Jadidi E, Moradi Gardeshi T. Protective Effects of Ginger Extract on Oxidative Stress and Steroidogenesis-related Genes in The Ovary of Streptozotocin-induced Diabetic Rats. IJML 2023; 10 (3) :254-263
URL: http://ijml.ssu.ac.ir/article-1-452-en.html
URL: http://ijml.ssu.ac.ir/article-1-452-en.html
Mehri Fallah Raoufi 
, Tahereh Mokhlesabadi Farahani 
, Elnaz Sadat Mousavi Sadr Jadidi , Tohid Moradi Gardeshi *
, Tahereh Mokhlesabadi Farahani , Elnaz Sadat Mousavi Sadr Jadidi , Tohid Moradi Gardeshi *
Department of Veterinary Sciences, Garmsar Branch, Islamic Azad University, Garmsar, Iran
Abstract: (376 Views)
Background and Aims: Ginger has anti-oxidant and anti-diabetic properties, but its beneficial effects have not been fully understood on ovarian disorders in diabetic conditions. In the current project, the impact of ginger extract was investigated on oxidative stress and steroidogenesis-related genes in streptozotocin (STZ)-induced female rats.
Materials and Methods: The STZ-induced rats were utilized as a diabetic model and received 200 or 400 mg/kg/day ginger extract for eight weeks. The biochemical factors were measured by standard procedures in this study. Serum levels of insulin and sex hormones were assessed by the enzyme-linked immunosorbent assay (ELISA) technique, and the mRNA expression of target genes was assayed by real-time polymerase chain reaction.
Results: An increase in the levels of glucose, testosterone, and malondialdehyde (MDA) as well as a decrease in the levels of insulin, glutathione peroxidase (GPx), 3β-hydroxysteroid dehydrogenase (3βHSD), steroidogenic acute regulatory protein (StAR), 17β-estradiol, and progesterone was observed in the diabetic rats. Ginger (200 mg/kg) exhibited a significant amelioration in the levels of glucose, testosterone, and MDA. Treatment with 200 mg/kg ginger enhanced the levels of GPx, StAR, and 17β-estradiol. Administration with 400 mg/kg ginger extract also ameliorated the level of glucose, testosterone, MDA, and elevated the level of insulin, GPx, 3βHSD, StAR, 17β-estradiol, and progesterone in the diabetic rats.
Conclusion: The current study suggests ginger extract protects against ovarian damage in STZ-diabetic rats.
Materials and Methods: The STZ-induced rats were utilized as a diabetic model and received 200 or 400 mg/kg/day ginger extract for eight weeks. The biochemical factors were measured by standard procedures in this study. Serum levels of insulin and sex hormones were assessed by the enzyme-linked immunosorbent assay (ELISA) technique, and the mRNA expression of target genes was assayed by real-time polymerase chain reaction.
Results: An increase in the levels of glucose, testosterone, and malondialdehyde (MDA) as well as a decrease in the levels of insulin, glutathione peroxidase (GPx), 3β-hydroxysteroid dehydrogenase (3βHSD), steroidogenic acute regulatory protein (StAR), 17β-estradiol, and progesterone was observed in the diabetic rats. Ginger (200 mg/kg) exhibited a significant amelioration in the levels of glucose, testosterone, and MDA. Treatment with 200 mg/kg ginger enhanced the levels of GPx, StAR, and 17β-estradiol. Administration with 400 mg/kg ginger extract also ameliorated the level of glucose, testosterone, MDA, and elevated the level of insulin, GPx, 3βHSD, StAR, 17β-estradiol, and progesterone in the diabetic rats.
Conclusion: The current study suggests ginger extract protects against ovarian damage in STZ-diabetic rats.
Type of Study: Research |
Subject:
Biochemistry
Received: 2022/06/29 | Accepted: 2022/08/14 | Published: 2023/10/2
Received: 2022/06/29 | Accepted: 2022/08/14 | Published: 2023/10/2
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