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Volume 2, Issue 2 (August 2015)                   IJML 2015, 2(2): 112-120 | Back to browse issues page

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Moulaei N, Khazaei H A, Pejman V. Assessment of Alpha-1 Antitrypsin Deficiency in Patients with Severe Chronic Obstructive Pulmonary Disease. IJML. 2015; 2 (2) :112-120
URL: http://ijml.ssu.ac.ir/article-1-55-en.html
Immunology and Hematology Department, Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Abstract:   (1714 Views)

Background and Aims: Chronic obstructive pulmonary disease (COPD) is a kind of pulmonary diseases characterized by chronic obstruction of lung that is in the form of a diffuse narrowing of airways resulting in air flow resistance. Alpha-1 antitrypsin (AAT) deficiency is genetically relatively common risk factor in patients with COPD throughout the world and the exact cause of its prevalence is unknown. We therefore performed a study to determine the frequency of AAT deficiency in patients with severe COPD compared to the healthy controls.
Materials and Methods: In this cross-sectional case control study, AAT serum level in 60 patients with severe COPD for whom the history and spirometry test with FEV1<50% had been confirmed based on gold criteria as well as 60 healthy controls, were tested using commercial kit and nephelometry method.
Results: The lowest serum levels of AAT measured in patients was <0.349 g/l and the highest was 3.099 g/l. These were obtained in healthy subjects as 1.180 g/l and 4.195 g/l respectively. Out of 60 patients, 4 (6.7%) had partial deficiency of AAT (AAT<1 g/l) and 6 (10%) had definite shortage of AAT (AAT<0.5 g/l). In healthy subjects, we did not find any definite and relative lack of AAT. The comparison of results obtained from these two groups indicated a significant difference between frequency of AAT (P=0.001).
Conclusions: Our findings revealed the frequency of AAT deficiency, as a factor involved in COPD disease, to be 10% and can be the reason for the high prevalence and severity of COPD in Zahedan city.

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Type of Study: Research | Subject: General
Received: 2015/08/18 | Accepted: 2015/08/18 | Published: 2015/08/18

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