en ژنتیک/ بیوتکنولوژی Genetics/ Biotechnology پژوهشي Research <p><strong>Background and Aims:</strong> This research aimed to study a possible link between endometriosis and polymorphism of the progesterone receptor gene.</p> <p><strong>Materials and Methods:</strong> The control group consisted of 86 women without endometriosis and the case group comprised 86 patients with a diagnosis of endometriosis by laparoscopy. Genotypes for Alu insertion polymorphisms (A1/A1, A1/A2 and A2/A2) were described by polymerase chain reaction and determined on a 2% agarousegel.</p> <p><strong>Results:</strong> The genotype frequencies of A1/A2 and A2/A2 were not significantly higher in patients than in the control group without endometriosis. On the other hand differences in the Alu insertion polymorphism frequencies were not significant.</p> <p><strong>Conclusion:</strong> According to our investigations, we conclude that there is not a significant correlation between Alu insertion polymorphism and endometriosis. ;line-height:115%&#39;> According to our investigations, we conclude that there is not a significant correlation between Alu insertion polymorphism and endometriosis.</p> <p></p> Endometriosis, Polymerase chain reaction, Progesterone receptor gene 185 190 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-24-8&slc_lang=en&sid=1 Mohammad Ataei No Department of Medical Genetics, International Campus, Shahid Sadoughi University of Medical Science, Yazd, Iran. Ehsan Farashahi No Department of Medical Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Science,Yazd, Iran. Morteza Seifati No Department of Genetics, Islamic Azad University, Ashkezar Branch,Yazd, Iran. Nasrin Ghasemi Yes Recurrent Abortion Research Centre, Reproductive Sciences Institute, Shahid Sadoughi University of Medicinal Sciences, Yazd, Iran.