fa ارزیابی ایمنی‌زایی علیه ویروس هپاتیت B در دانشجویان شاغل به تحصیل در رشته‌های مراقبت‌های پزشکی در ایران ایمنی شناسی Immunology پژوهشي Research <div style="text-align: justify;"><strong><span style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b zar;">مقدمه: بیماری هپاتیت </span></span></span></strong><strong><span dir="LTR" style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;">B</span></span></span></strong><strong><span style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b zar;"> بعنوان یکی از مشکلات عمده سیستم بهداشتی جهان مطرح می‌باشد. اخیرا، بدلیل پیدایش سیستم واکسیناسیون موثر علیه این بیماری، شیوع آن به میزان قابل توجهی کاهش یافته است. با این وجود در جمعیت افراد دارای خطر بالا، کاهش احتمال ابتلا به این بیماری علی‌الخصوص در میان دانشجویان و کارمندان شاغل در بخش‌های مختلف مراقبتهای سلامت با ایجاد ایمنی‌زایی موثر در مقابل این ویروس از اهمیت خاصی برخوردار است. ازین رو مطالعه حاضر در جهت بررسی ایمنی زایی موثر علیه بیماری هپاتیت </span></span></span></strong><strong><span dir="LTR" style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;">B</span></span></span></strong><strong><span style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b zar;"> پس از دریافت سه دوره واکسیناسیون کامل در دانشجویان دانشگاه علوم پزشکی ارومیه صورت گرفته است.</span></span></span></strong><strong><span style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;font-weight:normal;"><span style="color:black;"><span style="font-family:b zar;"></span></span></span></strong><br> <strong><span style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b zar;">مواد و روشها: دراین مطالعه پس از اخذ نمونه خون از دانشجویانی که سه نوبت منظم وکامل واکسن علیه ویروس هپاتیت</span></span></span></strong><strong><span dir="LTR" style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"> B</span></span></strong><span dir="LTR"><span style="color:black;"> (HBV)</span></span><strong><span style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b zar;"> رادریافت کرده بودند، میزان تیتر </span></span></span></strong><span dir="LTR"><span style="color:black;">Anti-HbsAg</span></span><strong><span style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b zar;"> با روش </span></span></span></strong><span dir="LTR"><span style="color:black;">Enzyme-linked immunosorbent assay</span></span> &nbsp;<strong><span dir="LTR" style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;">(ELISA)</span></span></strong><strong><span style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b zar;">مورد بررسی قرار گرفت. </span></span></span></strong><strong><span style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;font-weight:normal;"><span style="color:black;"><span style="font-family:b zar;"></span></span></span></strong><br> <strong><span dir="RTL" style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b zar;"><span style="font-size:11pt;">بحث و نتیجه‌گیری: براساس نتایج حاصل از مطالعه ما، در جمعیت مورد مطالعه، میانگین تیتر </span></span></span></span></strong><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:11.0pt;">Anti-HBsAg</span></span></span> <strong><span dir="RTL" style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b zar;"><span style="font-size:11pt;">به میزان </span></span></span></span></strong><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:11.0pt;">92.8&plusmn;80.5 mIU</span></span></span> <span dir="RTL"><span style="color:black;"><span style="font-family:b zar;"><span style="font-size:11.0pt;">گزارش گردید. براین اساس، درصد بالای جمعیت مورد مطالعه دارای تیتر بالای </span></span></span></span><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:11.0pt;">Anti-HBsAg</span></span></span><span dir="RTL"><span style="color:black;"><span style="font-family:b zar;"><span style="font-size:11.0pt;"> و ایمنی زا موثر بودند. همچنین دراین مطالعه، <strong><span style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;">تیتر انتی بادی </span></strong></span></span></span></span><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:11.0pt;">Anti-HBsAg</span></span></span> <span dir="RTL"><span style="color:black;"><span style="font-family:b zar;"><span style="font-size:11.0pt;">زنان بالاتر از مردان بود. درواقع اندازه گیری <strong><span style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;">تیتر </span></strong></span></span></span></span><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:11.0pt;">Anti-HBsAg</span></span></span><span dir="RTL"><span style="color:black;"><span style="font-family:b zar;"><span style="font-size:11.0pt;"> و بررسی ایمنی</span></span></span></span> <span dir="RTL"><span style="color:black;"><span style="font-family:b zar;"><span style="font-size:11.0pt;">زایی موثر میتواند به کاهش شیوع </span></span></span></span><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:11.0pt;">HBV</span></span></span><span dir="RTL"><span style="color:black;"><span style="font-family:b zar;"><span style="font-size:11.0pt;"> در دانشجویان<strong><span style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;">&nbsp; شاغل به تحصیل در رشته</span></strong></span></span></span></span><strong><span style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:calibri,sans-serif;"><span style="font-size:11pt;">‌</span></span></span></span></strong><strong><span dir="RTL" style="border:1pt none windowtext;padding:0cm;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="color:black;"><span style="font-family:b zar;"><span style="font-size:11pt;">های مراقبتهای پزشکی کمک شایانی نماید. درواقع کاهش شیوع </span></span></span></span></strong><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:11.0pt;">HBV</span></span></span><span dir="RTL"><span style="color:black;"><span style="font-family:b zar;"><span style="font-size:11.0pt;"> میتواند&nbsp; در نتیجه ایمنی زایی موثر برنامه واکسیناسیون ملی علیه این بیماری باشد.</span></span></span></span></div> <p style="text-align: justify;"><strong>Background and Aims:</strong> Hepatitis B virus (HBV) infection is a serious global health problem affects many people. Recently, because of vaccination, the incidence of HBV infection has been reduced, but in high risk population also health care students (HCS) adequate immunization is serious. The aim of this survey was to evaluate HBV immunization in the population of the paramedical students based on the demographic characteristics in Iran.</p> <p style="text-align: justify;"><strong>Materials and Methods:</strong> Anti-HBsAg titer was prospectively assayed in all vaccinated of the 95 HCS using Enzyme-linked immunosorbent assay.</p> <p style="text-align: justify;"><strong>Results and Conclusions:</strong> Anti-HBsAg titer in the studied population was estimated about 92.8&plusmn;80.5 mIU. Anti-HBsAg titer response was significantly higher in females to males. A low proportion of vaccinated HCS had low titers antibody against HBV infection. Therefore, measuring anti-HBsAg titer may help to drop in HBV incidence in HCS. This reduction can be correlated with the effectiveness of national immunization program.</p> ویروس هپاتیتB,Anti-HBsAg , دانشجویان رشته های مراقبتهای پزشکی, ELISA Hepatitis B virus, Health care student, ELISA , Anti-HBsAg 77 80 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-1-46&slc_lang=fa&sid=1 Zakieh Rostamzadeh Yes Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran. Mohadese Nemati No Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Mahshid Mohammadian No Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.