en بررسی ارتباط بین پلی مرفیسم ژن HLA با دیابت نوع 1 در بیمارانHLA rs3104413 ایمنی شناسی Immunology پژوهشي Research <div id="gt-lang-right"> <div id="gt-lang-tgt"><div id="gt-tl-sugg"></div></div> </div> <div id="gt-lang-submit"></div> <div id="gt-src-c"> <div id="gt-src-p"> <div id="gt-src-wrap"> <div><div dir="ltr"></div><textarea autocomplete="off" dir="ltr" id="source" name="text" spellcheck="false" tabindex="0" wrap="SOFT"></textarea></div> </div> </div> </div> <div style="text-align: justify;"><strong>Background and Aims: </strong>In this study, the effect of rs310441 polymorphism in the human leukocyte antigen (HLA) region on the development of susceptibility or resistance to Type 1 diabetes (T1D) among the people with T1D compared to healthy subjects has been investigated.<br> <strong>Materials and Methods</strong>: This research, which is based on the examination of 130 cases with T1D and 98 controls, has been carried out in the city of Hamedan after clinical examination. In order to determine the HLA gene polymorphism, the allele-specific-refractory mutation system-polymerase chain reaction (ARMS-PCR) method was utilized.<br> <strong>Results:</strong> This study indicated that there is a significant relationship between the frequency of alleles and genotypes in the patients compared to healthy subjects. The C/C and C/G genotypes were more frequent in patients than controls and G/G genotype was shown to be protective for T1D (p=0.01). Significant difference was found for the G allelic frequency in patients with T1D and in the control group. The allelic frequency was significantly different between the two groups (p=0.0001)<span dir="RTL">.</span> Our findings indicate that HLA polymorphism(C/G) and (C/C) genotypes could be considered as genetic risk factors associated with susceptibility and (G/G) genotypes associated with protection for T1D.<br> <strong>Conclusions: </strong>This study identified that there is a significant relationship between the frequency of alleles and genotypes in the patients compared to healthy subjects.</div> دیابت نوع یک, پلی مورفیسم تک نوکلوتیدی ,ژن HLA HLA, Single nucleotide polymorphisms, Type 1 Diabetes 42 48 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-216-1&slc_lang=en&sid=1 Sepideh Jamehbozorg No Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Gilda Eslami No Research Center for Food Hygiene and Safety, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Ghasem Solgi No Department of Immunology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Hamzeh Rezaei No Department of Immunology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Mehrdad Hajilooi No Department of Immunology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Morteza Samadi Yes Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran