International Journal of Medical Laboratory
مجله بین المللی علوم آزمایشگاهی
IJML
Medical Sciences
http://ijml.ssu.ac.ir
1
admin
2423-3706
2423-3714
en
jalali
1397
8
1
gregorian
2018
11
1
5
4
online
1
fulltext
en
بررسی وضعیت آهن و اسکلروستین در بیماران تالاسمی
Survey of the Status of Iron and Sclerostin in Major Thalassemia Patients
خون شناسی و بانک خون
Hematology & Blood Banking
پژوهشي
Research
<div><strong>Abstract<a name="_GoBack"></a></strong></div>
<div style="text-align: left;"><strong>Background and aims:</strong> Thalassemia is one the most prevalent genetic anemia in the world; homozygote patients usually suffer from sevewr disturbances .Osteopenia and osteoporosis are of thalassemia complications which are increasing the rate in patients with iron load conditions. Sclerostin is a protein which enhances bone loss by inhibiting osteoblasts. The aim of this study was to measure sclerostin protein and its association with iron overload in patients with thalassemia.<br>
<strong>Materials and methods: </strong>Serum was isolated from 40 patients with beta-Thalassemia and 40 healthy control individuals. Sclerostin protein and ferritin were evaluated using ELISA method.<br>
<strong>Results: </strong>mean sclerostin proteins were 100.7 pg/ml, in the case group; it was 143.1 pg/ml in the control group, There was no significant differences between sclerostin protein in case and control group (p = 0.015). The association of sclerostin and ferritin was not significant in the case group (P = 0.7) ; it was significant in the control group (P = 0.037).<br>
<strong>Conclusion: </strong>Our findings suggest that sclerostin protein signaling can play an important role in the pathogenesis of osteoporosis.</div>
<div></div>
<strong>Background and Aims</strong><strong>:</strong> Thalassemia is one the most prevalent genetic anemia in the world; homozygote patients usually suffer from severe disturbances. Osteopenia and osteoporosis are of various types of thalassemia complications which increase in rate in patients with iron overload conditions. Sclerostin is a protein which enhances bone loss by inhibiting osteoblasts. The aim of this study was to measure sclerostin protein and its association with iron overload in major thalassemia patients.<span dir="RTL"></span><br>
<strong>Materials and Methods: </strong>Forty patients with major beta-Thalassemia and 40 healthy control individuals were includedin the study; Sclerostin protein and ferritin were evaluated using enzyme-linked immunosorbent assay method.<br>
<strong>Results:</strong> Mean sclerostin protein was 100.7 pg/ml, in the case group; it was 143.1 pg/ml in the control group.There was a significant differences between sclerostin protein in case and control groups (p= 0.01). The association of sclerostin and ferritin was not significant in the case group (p= 0.7), while it was meaningful in the control individuals (p= 0.04).<br>
<strong>Conclusions: </strong>Our findings suggest that sclerostin protein can play an important role in the pathogenesis of osteoporosis.
beta-Thalassemia, Iron, sclerostin protein, ferritin, ELISA.
Beta-thalassemia, Ferritin, Iron, Sclerostin protein
288
293
http://ijml.ssu.ac.ir/browse.php?a_code=A-10-221-1&slc_lang=en&sid=1
Leila
Moinzadeh
sss@yahoo.com