en ژنتیک/ بیوتکنولوژی Genetics/ Biotechnology پژوهشي Research <div style="text-align: justify;"><span style="font-family:times new roman;"><strong>Background and Aims:</strong> An impairment of expression in MLL2 gene involved in histone methylation induces alteration in the methylation patterns at enhancers and causes several cancers including colon cancer. In this study, MLL2 expression was evaluated in North West of Iran.<br> <strong>Materials and Methods:</strong> To evaluate the MLL2 expression in patients with colon cancer, 25 tumor samples and 25 samples of tumor margins were collected and analyzed by real-time polymerase chain reaction.<br> <strong>Results:</strong> KMT2B level was not associated with age (p=0.3), gender (p=0.05) and tumor size (p=0.2) but had relation with stage of tumor (p=0.04).<br> <strong>Conclusions:</strong> According to the results obtained from investigating<br> the MLL2 gene expression, it was found that it has a significant relationship with the stage of tumor.</span></div> colorectal cancer, , MLL2 gene expression, methyltransf Colorectal cancer, Histone methylation, Methylation, MLL2 208 213 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-238-1&slc_lang=en&sid=1 Arezoo Faramarzi No Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. Reza Safaralizadeh Yes Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. Mohammadali Hosseinpourfeizi No Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. Yaghoub Moaddab No Liver and Gastroenterology Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran