en ژنتیک/ بیوتکنولوژی Genetics/ Biotechnology پژوهشي Research <div style="text-align: justify;"><strong>Background and Aims:</strong> Chronic lymphocytic leukemia (CLL) is the most common adult human leukemia. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Research has shown that in CLL, microRNAs can have function as oncogenes or tumor suppressors. Some studies demonstrated that the expression of microRNA-93 (<em>miR-93</em>) and microRNA-330<em> (miR-330)</em> have been changed in several cancers, including lung, prostate, and colon cancer. We aimed to elucidate the changes in <em>miR-93</em> and <em>miR-330</em> expression in CLL patients in comparison with controls.<br> <strong>Materials and Methods</strong>: In this case-control study, the expression levels of <em>miR-93</em> and <em>miR-330</em> was evaluated in 30 CLL patients who had referred to Omid Hospital, Isfahan, Iran, and 30 controls in peripheral blood mononuclear cells using reverse transcription quantitative PCR (RT-qPCR).<br> <strong>Results:</strong> The expression of miR-93 and miR-330 were found to significantly increase in CLL patients compared with controls (p<0.0001).<br> <strong>Conclusions: </strong>The findings indicated that <em>miR-93 </em>and<em> miR-330</em> are probably the novel potential biomarker for early diagnosis of CLL, at least in Iranian patients. However, for a decisive result, further investigations are warranted.&nbsp;</div> -- Chronic lymphocytic leukemia, , microRNA, miR-93, miR-330 100 106 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-286-1&slc_lang=en&sid=1 Behnaz Nateghi بهناز ناطقی Behnaz.nateqi@gmail.com 0000-0001-9790-6658 No Department of Biochemistry, Faculty of Science, Nourdanesh Institutions of Higher Education, Meimeh, Isfahan, Iran Department of Biochemistry, Faculty of Science, Nourdanesh Institutions of Higher Education, Meimeh, Isfahan, Iran Elaheh Shams الهه شمس Behnaz.nateqi@gmail.com 0000-0003-0952-038X No Young Researchers and Elite Club, Falavarjan Branch, Islamic Azad University, Isfahan, Iran. Young Researchers and Elite Club, Falavarjan Branch, Islamic Azad University, Isfahan, Iran. Parisa Behshood پریسا بهشود Behnaz.nateqi@gmail.com 0000-0003-4688-2144 No Department of Microbiology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran. Department of Microbiology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran. Sima Fathullahzadeh سیما فتح اله زاده Behnaz.nateqi@gmail.com 0000-0002-5510-9009 No Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran. Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran. Mansoor Salehi منصور صالحی M_salehi@med.mui.ac.ir 0000-0002-6565-0907 Yes Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran