International Journal of Medical Laboratory
مجله بین المللی علوم آزمایشگاهی
IJML
Medical Sciences
http://ijml.ssu.ac.ir
1
admin
2423-3706
2423-3714
en
jalali
1398
11
1
gregorian
2020
2
1
7
1
online
1
fulltext
en
IL-8 May Be the Target of Arsenic in Human Breast Milk
ایمنی شناسی
Immunology
پژوهشي
Research
<div style="text-align: justify;"><strong>Background and Aims:</strong> The critical aim of this study was to evaluate the effects of breast-milk contamination with Nickel and Arsenic, as well as aflatoxin M1 (AFM1) on the milk levels of IL-6 and IL-8. <br>
<strong>Materials and Methods: </strong>Breast milk was collected from 76 mothers on the 30<sup>th</sup> day post-parturition and milk levels of AFM1, Nickel, Arsenic, IL-6 and IL-8 were evaluated.<br>
<strong>Results: </strong>The results showed 8 and 29 out of 76 collected samples being contaminated with AFM1, Nickel and Arsenic, respectively. Levels of IL-6 and IL-8 in the milk samples did not differ in AFM1 and Nickel and Arsenic contaminated milk compared with the normal controls (non-contaminated milks). There was a moderate positive relation between milk levels of IL-8 and Arsenic.<br>
<strong>Conclusions: </strong>Although AFM1, Nickel and Arsenic are the inducers of cytokine production; they are unable to induce secretion of IL-6 in breast milk. Arsenic can be a trigger of IL-8, which is a strong chemoattract for neutrophils. Thus, it appears that Arsenic may induce an inflammation in milk in IL-8 dependent manner.<br>
</div>
Aflatoxin M1, Arsenic, IL-6, IL-8, Nickel
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48
http://ijml.ssu.ac.ir/browse.php?a_code=A-10-329-1&slc_lang=en&sid=1
Khodayar
Ghorban
خدایار
قربان
kh.ghorban@gmail.com