en باکتری شناسی Bactriology پژوهشي Research <div style="text-align: justify;"><strong>Background and Aims:</strong> Integrons as mobile genetic elements are located on the chromosome or on a plasmid in bacteria. Integrons play a main role in the dissemination of antibiotic resistance genes among different families of bacteria. The aim of this study was to identify the prevalence of class 1 integron in <em>Klebsiella pneumoniae </em>isolates from hospitals of Sanandaj, Kurdistan province, Iran.<br> <strong>Materials and Methods:</strong> Seventy <em>Klebsiella pneumoniae </em>isolates were collected from Hospitals of Sanandaj. Antibiotic susceptibility pattern was performed by disc diffusion method. Class 1 integrons gene was screened by polymerase chain reaction assay. Data were analyzed by Fisher tests with STATA software program.<br> <strong>Results:</strong> The highest and lowest rates of resistance were related to cefotaxime and imipenem, respectively. Thirteen (18.5%) out of 70 <em>Klebsiella pneumoniae </em>isolates caring class 1 integron gene. Out of 28 multidrug resistant isolates, 11 isolates were identified to be positive for the existence of class 1 integrons.<br> <strong>Conclusions:</strong> class 1 integron positive isolates, compared to class 1 integron negative isolates, reveals resistance to more antibiotics. &nbsp;<br> &nbsp;</div> Class 1 Integron, Klebsiella pneumoniae, disc diffusion method, PCR assay Class 1 Integron, Klebsiella pneumoniae, PCR assay 35 40 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-356-1&slc_lang=en&sid=1 pegah shakib پگاه شکیب shakib.pegah@yahoo.com 0000-0003-3525-226X Yes Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. مرکز تحقیقات داروهای گیاهی دانشگاه علوم پزشکی لرستان