en ایمنی شناسی Immunology پژوهشي Research <strong>Background and Aims:</strong> Multiple sclerosis (MS) is known as a partially inheritable inflammatory autoimmune disease which involves the nervous system. Different studies suggest that immune dysregulation has an important role in the pathogenesis of MS, but its exact pathomechanism has not yet been explicated. The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules. In MS patients, the expression of membrane-bound RAGE on&nbsp;<a href="https://www.sciencedirect.com/topics/neuroscience/peripheral-blood-mononuclear-cell" title="Learn more about Peripheral Blood Mononuclear Cell">peripheral blood mononuclear cells</a>, as well as the serum levels of the RAGE ligands are upregulated.<br> <strong>Materials and Methods: </strong>In this case-control study, we evaluated the association between MS incidence and <em>RAGE p.82G>S</em> polymorphism (rs2070600) compared with healthy controls in an Iranian population. A total of 158 patients and 156 healthy blood donors were enrolled. This polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism.<br> <strong>Results: </strong>Allele frequencies (p=0.319) and genotype distribution (p=0.315) of the RAGE p.82G>S gene polymorphism in MS patients and controls were not significantly different.<br> <strong>Conclusions:</strong> The present study indicated no relationship between RAGE p.82G>S polymorphism and the risk of MS in Iranian population.<br> &nbsp; Advanced glycation end product, Multiple sclerosis, Polymorphism 15 22 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-357-1&slc_lang=en&sid=1 Hamideh Valizadeh حمیده ولی زاده hamidehvalizadeh164@gmail.com No Department of Immunology, Faculty of Medicine, International Campus of Shahid Sadoughi University of Medical Sciences, Yazd, Iran. ایران، یزد، شعبه بین الملل دانشگاه علوم پزشکی شهید صدوقی یزد Gilda Eslami گیلدا اسلامی Eslami_g2000@yahoo.com 0000-0002-4521-4059 No Research Center for Food Hygiene and Safety, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. ایران- یزد- دانشگاه علوم پزشکی شهید صدوقی یزد،گروه انگل شناسی Reyhane Rahnama ریحانه رهنما reyhane.rahnama@yahoo.com 0000-0002-7938-5040 No Department of Immunology, Faculty of Medicine, Isfahan University of Medical Science, Isfahan, Iran. ایران، اصفهان، دانشگاه علوم پزشکی اصفهان، گروه ایمنی شناسی پزشکی Abolghasem Rahimdel ابوالقاسم رحیم دل Rahimdel30142@yahoo.com No Department of Neurology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. ایران، یزد، بیمارستان شهید صدوقی یزد، دپارتمان نورولوژی Fateme sadat Dashti فاطمه السادات دشتی fs.dashti64@gmail.com No Reproductive Immunology Reseach Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ایران، یزد، دانشگاه علوم پزشکی شهید صدوقی یزد، مرکز تحقیقات ایمنولوژی تولید مثل Reza Mansouri رضا منصوری rezamansouri903@gmail.com 0000-0002-7260-4263 Yes Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ایران، یزد، دانشگاه علوم پزشکی شهید صدوقی یزد، گروه ایمنی شناسی پزشکی