en The effects of aqueous extract of Boswellia Serrata on memory impairment induced by Lipopolysaccharide in rat بیوشیمی Biochemistry پژوهشي Research <strong>Introduction:</strong> The therapeutic effects of the olibanum, the resin of <em>Boswellia serrata</em><br> (<em>B. serrata</em>) from <em>Burseracea</em> family in inflammatory disease have been reported. There are more than 200 active ingredients in this resin including <em>Boswellic acid</em> (BA). We are proposed that aqueous extract of <em>Boswellia Serrata </em>can improve memory impairment induced by cerebral inflammation result in administration of lipopolysaccharide (LPS).<br> <strong>Methods:</strong> In the current study, the neuroprotective effects of aqueous extract of<br> <em>Boswellia Serrata </em>were investigated against LPS -induced spatial memory disorders in rats. In this study, after treatment of rat with LPS, brain toxicity induction was performed and finally, the behavioral tests were evaluated. Following cerebral inflammation induction and treatment, learning and memory performance and biochemistry tests were assessed in all groups.<br> <strong>Results: </strong>LPS administration increased the duration and distance to find the platform in the Morris water maze (MWM) test in compare to control group in 5 days (P<0.05 to P<0.001) while, LPS decreased the latency to enter to the dark compartment after receiving the sock in passive avoidance (PA) test (P<0.001). Pretreatment with both doses of aqueous extract of <em>Boswellia Serrata </em>enhanced performances of the rats in MWM (P<0.05 to P<0.01) and PA test (P<0.01 to P<0.001). LPS also increased hippocampus IL-6, MDA levels (P<0.001).<br> <strong>Conclusion:</strong> Aqueous extract of <em>Boswellia Serrata </em>can be used as an effective drug in memory impairment caused by LPS-induced inflammation.<br> &nbsp; <div style="text-align: justify;"><strong>Background and Aims:</strong> The therapeutic effects of the olibanum, the resin of <em>Boswellia serrata (B. serrata</em>) from the Burseraceae family in inflammatory disease have been reported. There are more than 200 active ingredients in this resin, including Boswellic acid. It is proposed<br> that aqueous extract of <em>B. serrata </em>can improve memory impairment induced by cerebral inflammation result in the administration of lipopolysaccharide (LPS).<br> <strong>Materials and Methods:</strong> In this study, after the treatment of rats with LPS, brain toxicity induction was performed, and finally, the behavioral tests were evaluated. Following cerebral inflammation induction and treatment, behavioral performance biochemistry tests and molecular methods were assessed in all groups.<br> <strong>Results: </strong>LPS administration increased the duration and distance to find the platform in the Morris water maze test compared to the control group in 5 days (p<0.05 to p<0.001). Furthermore, LPS reduced the peripheral, central, and total locomotion compared to the control group (p< 0.001) in the open field test. Pretreatment with both doses of aqueous extract of <em>B.&nbsp;serrata </em>enhanced performances of the rats in Morris water maze (p<0.05 to p<0.01) and open field test (p<0.01 to p<0.001). LPS also increased hippocampus Interleukin-6, malondialdehyde levels (p<0.001).<br> <strong>Conclusion:</strong> Aqueous extract of <em>B. serrata </em>can be a useful drug in memory impairment caused by LPS-induced inflammation.</div> Keywords: Boswellia Serrata, Memory impairment, Inflammation, oxidative stress Boswellia Serrata, Inflammation, Memory impairment, Oxidative stress 300 311 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-68-7&slc_lang=en&sid=1 Samaneh Borooni samaneh Borooni smaragd.black@gmail.com 0000-0003-0211-8865 No Department of Biology, Nourdanesh Institute of Higher Education, Meymeh, Isfahan, Iran Department of Biology, Nourdanesh Institute of Higher Education, Meymeh, Esfahan, Iran. Fahimeh Nourbakhsh Fahimeh Nourbakhsh nourbakhshf951@mums.ac.ir 0000-0001-5576-7274 Yes Medical Toxicology Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Medical Toxicology Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Elahe Tajbakhsh Elaheh Tajbakhsh fahimeh_nourbakhsh@yahoo.com 0000-0002-1073-5954 No Department of Microbiology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran Department of Microbiology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran Parisa Behshood Parisa Behshood fahimeh_nourbakhsh@yahoo.com 0000-0003-4688-2144 No Department of Microbiology, Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran PHD student, department of microbiology, young researchers and elite club, Shahrekord branch, Islamic Azad University, Shahrekord, Iran.