en Evaluation of Serum Iron Indices of Pregnant Women attending Abuja Teaching Hospital, Nigeria خون شناسی و بانک خون Hematology & Blood Banking پژوهشي Research <div wfd-id="0">Background:<br> Iron Deficiency Anemia (IDA) is common obstetric problem and nutritional disorder in developing countries. However, there is paucity of studies that evaluated the iron indices of pregnant women to augment diagnosis of IDA and associated disorders.<br> Objective:<br> This cross-sectional study evaluated the serum iron, ferritin, transferrin, total iron binding capacity (TIBC) and Unsaturated iron binding capacity (UIBC) of pregnant women attending University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria.<br> Materials and methods:<br> Blood samples was collected from 58 non-pregnant women, 22 pregnant women at first trimester, 52 in 2^nd and 44 in 3^rd trimester. The serum ferritin concentration of these samples was measured by Chemiluminescence Assay (CLIA) while the serum transferrin, total iron binding capacity and iron concentrations were measured by Enzyme Linked Immunosorbent Assay (ELISA). IDA was defined as serum ferritin levels <em><</em>15&mu;g/L<br> Results:<br> The overall prevalence of IDA in pregnant women was 33.1%. However, the prevalence of IDA was 29.3%, 22.7%, 34.6% and 36.4% among non-pregnant women, women at 1^st trimester, 2^nd and 3^rd trimester, respectively. The mean+SD Iron levels was significantly higher among pregnant women than the non-pregnant women (p=0.004). There was no significant difference in the mean+SD serum ferritin, transferrin, TIBC concentration between pregnant and non-pregnant women (p˃0.05). However, the mean+SD serum iron, ferritin and UIBC significantly differ from across gestation age of pregnant women (p˂0.05).<br> Conclusion:<br> This study revealed a high level of IDA during pregnancy and this increases with the trimester of pregnant women. Healthcare interventional measures that could address this nutritional and metabolic disorder are recommended.</div> <div style="text-align: justify;"><strong>Background and Aims:</strong> Iron Deficiency (ID) is a common obstetric problem and nutritional disorder that occurs mostly in developing countries. Hence, nutritional studies are required every few years to determine the necessary healthcare interventions for pregnant women. This cross-sectional study evaluated the plasma iron, ferritin, transferrin, total iron-binding capacity (TIBC), and unsaturated iron-binding capacity (UIBC) levels of pregnant women referred to the University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria.<br> <strong>Materials and Methods:</strong> Blood samples were collected from 58 non-pregnant women, 22 pregnant women in the first trimester, 52 in second, and 44 in the third trimester. The plasma ferritin concentration of these samples was measured by chemiluminescence assay, while the plasma transferrin, TIBC, and iron concentrations were measured by enzyme-linked immunosorbent assay. Plasma ferritin levels <em><</em>15&mu;g/L were considered ID.<br> <strong>Results:</strong> The overall prevalence of ID in pregnant women was 33.1%. However, the prevalence of ID was 29.3%, 22.7%, 34.6%, and 36.4% among non-pregnant women, women in the first trimester, second and third trimester, respectively. The mean&plusmn;SEM iron levels were significantly higher among pregnant women compared to non-pregnant women (p=0.004). There was no significant difference in the mean&plusmn;SEM of plasma ferritin, transferrin and TIBC concentrations between pregnant and non-pregnant women (p>0.05). Nevertheless, the mean&plusmn;SEM plasma iron, ferritin, and UIBC significantly differed across the gestational ages of pregnant women (p<0.05).<br> <strong>Conclusions:</strong> This study revealed a high prevalence of ID during pregnancy, which increases with the trimester of affected women. Healthcare interventional measures that can address ID are recommended.</div> Nutritional disorder, Iron metabolism, Anemia, Pregnancy, Nigeria 168 178 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-348-3&slc_lang=en&sid=1 Amos Dangana Amos Dangana amosd@yahoo.com No Department of Medical Laboratory Services, University of Abuja Teaching Hospital, Gwagwalada, Abuja Nigeria, Department of Medical Laboratory Services, University of Abuja Teaching Hospital, Gwagwalada, Abuja Nigeria, Anthony Uchenna Emeribe Anthony Uchenna Emeribe uemeribe@yahoo.com No Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria Sanusi Musa Sanusi Musa Sanusymusa@gmail.com No Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria Lugos Moses ldluos@gmail.com No Department of Medical Laboratory Science, University of Jos, Jos, Nigeria Department of Medical Laboratory Science, University of Jos, Jos, Nigeria Christopher Ogar Christopher Ogar chrisoga@yahoo.com No Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria Charles Ugwu Charles Ugwu Charlesu@yahoo.com No Department of Medical Laboratory Science, Ebonyi State University, Abakaliki, Nigeria, Department of Medical Laboratory Science, Ebonyi State University, Abakaliki, Nigeria, Chibueze Obi-George Chibueze Obi-George chinb@yahoo.com No Department of Medical Laboratory Science, University of Nigeria, Enugu, Nigeria Department of Medical Laboratory Science, University of Nigeria, Enugu, Nigeria Jessy Medugu Jessy Medugu jessytm@yahoo.com No Department of Medical Laboratory Science, University of Maiduguri, Maiduguri, Nigeria Department of Medical Laboratory Science, University of Maiduguri, Maiduguri, Nigeria Olasoji Matthew Billyrose Olasoji Matthew Billyrose olasojinnn@yahoo.com No Department of Medical Laboratory Services, University of Abuja Teaching Hospital, Gwagwalada, Abuja Nigeria Department of Medical Laboratory Services, University of Abuja Teaching Hospital, Gwagwalada, Abuja Nigeria Idris Nasir Abdullahi Idris Nasir Abdullahi eedris888@yahoo.com 0000-0002-5511-1272 Yes Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria, Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria,