en ژنتیک/ بیوتکنولوژی Genetics/ Biotechnology پژوهشي Research Suitable alternatives are made for damaged or diseased organs and tissues in tissue engineering by combining cellular and molecular biology with materials and mechanical engineering. Fibrin is a critical blood component responsible for homeostasis, used extensively as a biopolymer scaffold in tissue engineering. This study summarizes the latest developments in organ and tissue regeneration using fibrin as a scaffold material. The combination of active peptides and growth factors through a heparin-bound delivery system improves fibrin function as a scaffold. Besides, the development of fibrin precursors as recombinant proteins solves multiple or single donor fibrin adhesives. Its composite allows biomolecules to be combined with fibrin and can significantly enhance fibrin efficacy in cartilage tissue engineering applications. Fibrin, Fibrinogen, Fibrin Composite, Cartilage, Scaffold 1 9 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-379-2&slc_lang=en&sid=1 Majid Pourentezari مجید پورانتظاری m.pourentezari@gmail.com 0000-0001-7549-4672 No Department of Anatomy and Molecular Biology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Morteza Anvari مرتضی انواری m.pourentezari@gmail.com No Department of Anatomy and Molecular Biology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Maryam Yadegari مریم یادگاری m.pourentezari@gmail.com 0000-0003-0746-2622 No Department of Anatomy and Molecular Biology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Abolghasem Abbasi ابوالقاسم عباسی m.pourentezari@gmail.com No Department of Anatomy and Molecular Biology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Hengameh Dortaj هنگامه درتاج hengameh.dourtaj@gmail.com 0000-0002-4523-2716 Yes Department of Tissue Engineering and Applied Cell Science, Shiraz University of Applied Medical Science and Technologies, Shiraz, Iran