International Journal of Medical Laboratory
مجله بین المللی علوم آزمایشگاهی
IJML
Medical Sciences
http://ijml.ssu.ac.ir
1
admin
2423-3706
2423-3714
en
jalali
1401
5
1
gregorian
2022
8
1
9
3
online
1
fulltext
en
Identification of First Patient with Rh null Phenotype in Southeast Iran
خون شناسی و بانک خون
Hematology & Blood Banking
گزارش مورد
case report
<br>
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<div style="text-align: justify;"><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:115%">Background and Aims: </span></span></b><span style="font-size:10.0pt"><span style="line-height:115%">Rh<sub>null, </sub>with an estimated incidence of one per 6,000,000 individuals, is an extremely rare disorder with an autosomal recessive pattern of inheritance that is more common in societies with a high rate of consanguinity. </span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:115%">Materials and Methods:</span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:115%">In this study, we report the first case with Rh<sub>null, </sub>a blood group phenotype in southeast Iran, which was diagnosed during pretransfusion testing. </span></span></span></span></span><br>
<b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Results and Conclusions:</span></span> </b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">A 21-year-old woman with a positive parents' consanguineous marriage was found to have an unusual reaction with all packed red blood cell units during routine pretransfusion cross-match testing in the hospital. The patient's serum was reacted with all screening and identification panel cells, suspected to have an alloantibody against a common antigen or multiple alloantibodies against her absence antigens. Further studies revealed negative results for C, c, E, and e, which are highly suspected of Rh<sub>null</sub> phenotype. Confirmatory assessments were performed, including adsorption and elution studies and Rh phenotyping of patients, along with known positive and negative controls. Due to the blood requirement of the patient, we performed serological studies on the patient's family members and found that her sister also has a Rh<sub>null</sub> phenotype. Blood transfusion from her sister's donated units was performed, and the pregnancy was ended without any complications. Finally, due to the rarity of the Rh<sub>null </sub>phenotype, early identification of individuals and autologous or compatible allogeneic blood transfusion should be planned prior to selective or emergency surgeries. </span></span><span style="font-size:11.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> </span></span></span></div>
Alloantibody,
Rare blood group, Rh null, Transfusion reaction
164
168
http://ijml.ssu.ac.ir/browse.php?a_code=A-10-424-1&slc_lang=en&sid=1
Hassan
Bahramian
حسن
بهرامیان
hassanbahramiyan@gmail.com