en ژنتیک/ بیوتکنولوژی Genetics/ Biotechnology پژوهشي Research <div style="text-align: justify;"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Recently, it has been proven that cartilage healing is difficult. The most commonly used treatments are autogenously cartilage grafting and allogeneic bone grafting, but grafts cannot fully meet treatment goals because of source, price, safety, and other concerns. Thus, a combination of biological materials and tissue engineering technology has become a recent trend in studies. Among the studies performed on tissue engineering cartilage materials are hydrogels that exhibit biological activity, post-decomposition adsorption, flexibility, and easy preparation. Cell-containing hydrogels are often used in cartilage tissue engineering because of their biocompatibility, ease of use, and ability to adapt to different defects. Hydrogels are used to mimic extracellular matrices. Although multiple materials can configure and form hydrogels, hyaluronic acid and its derivatives are distinguished. Hyaluronic acid (HA) is an extracellular molecule with several physical and biological functions found in many tissues, including cartilage. HA is formed in several biomaterial systems and scaffolding. HA hydrogels have many interests, including increased adhesion, cell proliferation, and wound healing. In addition, they represent adequate biological acting for stimulating a microenvironment for the survival of cells. However, their disadvantages include a slow degradation rate and low mechanical properties. Here, HA-based hydrogels and their applications in cartilage tissue engineering are briefly reviewed.</span></span></div> Cartilage regeneration, Chondrogenesis, Hyaluronic acid, In vitro, Scaffold 6 16 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-379-4&slc_lang=en&sid=1 Ali Rajabi علی جبالی m.pourentezari@gmail.com 0000-0002-9491-0093 No Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran مرکز تحقیقات غدد، دانشگاه علوم پزشکی شهید صدوقی، یزد، ایران Majid Pourentezari مجید پورانتظاری m.pourentezari@gmail.com 0000-0001-7549-4672 Yes Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran مرکز تحقیقات غدد، دانشگاه علوم پزشکی شهید صدوقی، یزد، ایران Hengameh Dortaj هنگامه درتاج m.pourentezari@gmail.com 0000-0002-4523-2716 No Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran مرکز تحقیقات غدد، دانشگاه علوم پزشکی شهید صدوقی، یزد، ایران Abbas Shahedi عباس شاهدی m.pourentezari@gmail.com 0000-0002-9445-3806 No Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran مرکز تحقیقات غدد، دانشگاه علوم پزشکی شهید صدوقی، یزد، ایران Maryam Yadegari مریم یادگاری m.pourentezari@gmail.com 0000-0003-0746-2622 No Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran مرکز تحقیقات غدد، دانشگاه علوم پزشکی شهید صدوقی، یزد، ایران sepideh Izadi سپیده ایزدی m.pourentezari@gmail.com 0000-0002-8222-4424 No Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran مرکز تحقیقات غدد، دانشگاه علوم پزشکی شهید صدوقی، یزد، ایران Fatemeh Zakizadeh فاطمه زکی زده m.pourentezari@gmail.com 0000-0002-6897-7016 No Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran مرکز تحقیقات غدد، دانشگاه علوم پزشکی شهید صدوقی، یزد، ایران Zeinolabedin Sharifian Dastjerdi زین العابدین شریفیان m.pourentezari@gmail.com 0000-0002-3092-0284 No Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran مرکز تحقیقات غدد، دانشگاه علوم پزشکی شهید صدوقی، یزد، ایران