en آسیب شناسی Pathology پژوهشي Research <div style="text-align: justify;"><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:115%">Background and Aims: </span></span></b><span style="font-size:10.0pt"><span style="line-height:115%">Limited information is available on the frequency of advanced adenomas in diminutive colon polyps. Thus, this study aimed to investigate the pathological characteristics and the frequency of high-grade dysplasia in diminutive colorectal polyps in individuals referred to colonoscopy examination in Kermanshah, Iran. </span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:115%">Materials and Methods:</span></span></b> <span style="font-size:10.0pt"><span style="line-height:115%">Demographics characteristics, location and diameter of the polyp, histological assessment of the polyps, grade, and others were retrieved from colonoscopy reports. </span></span></span></span></span><br> <b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Results and Conclusions: </span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">During the study period</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">, 250 diminutive colorectal<b> </b>polyps were detected. The histological assessment showed that 36.4% were adenomatous, 32.8% were hyperplastic, and 30.8% were inflammatory polyps. Only two diminutive polyps (0.8%) had high-grade dysplasia, and the frequency of adenocarcinoma in our study was 0.4%. Besides, the frequency of adenomatous polyps was higher in the proximal versus the distal colon. These findings emphasize the urgent need for a colorectal cancer</span></span> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">screening plan in the Iranian population to improve therapeutic outcomes.</span></span></div> Adenomatous polyps, Colonoscopy, Diminutive colorectal polyps, Histopathology 1 6 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-467-1&slc_lang=en&sid=1 Homayoon Bashiri همایون بشیری hbashirimd@yahoo.com 0000-0002-7056-6478 No Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran مرکز تحقیقات بیماری های عفونی، دانشگاه علوم پزشکی کرمانشاه Mahsa Madani lotfollah.asgari@yahoo.com No Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran Lotfollah Asgari لطفالله عسگری No Department of Internal Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran Arezoo Bozorgomid آرزو بزرگ امید 0000-0003-2093-9317 Yes Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran