International Journal of Medical Laboratory

en Evaluation of Biological Markers in Children's Cerebrospinal Fluid with Bacterial and Viral Meningitis باکتری شناسی Bactriology پژوهشي Research <div style="text-align: justify;">Background and Aims: Cerebrospinal fluid (CSF) and blood biomarkers are widely evaluated as diagnostic tools to distinguish between bacterial meningitis and viral meningitis in emergency laboratory tests. So, this aimed to examine the levels of diagnostic parameters in blood and CSF to discriminate between bacterial and viral meningitis in young children referred to Khoy Hospital. Materials and Methods: A total of 101 young children with meningitis were enrolled in this prospective study. The diagnosis of bacterial and viral meningitis was based on clinical features and laboratory findings. Results: Of the 101 patients with meningitis, 18 (17.82%) were bacterial, and 83 (82.17%) were viral meningitis. The levels of CSF glucose and CSF/blood glucose ratio were significantly lower in the bacterial meningitis group than in the viral meningitis group (p < 0.01). In contrast, white blood cells count, CSF protein, interleukin-6, C-reactive protein, and ferritin levels were significantly higher in patients with bacterial meningitis compared to viral meningitis (p < 0.01). However, there was no difference between viral and bacterial meningitis groups concerning mean serum glucose. Conclusion: This study suggests that decreased CSF glucose and CSF/blood glucose ratio and increased white blood cells count, CSF protein, ferritin, interleukin-6, and C-reactive protein combined with clinical symptoms can help better diagnosis of bacterial meningitis, especially in comparison with viral meningitis.</div> Bacterial meningitis, Biological marker, Cerebrospinal fluid, Viral meningitis 208 216 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-488-1&slc_lang=en&sid=1 Mohammad Panji محمد پنجی mohammadpanji2016@gmail.com 0000-0003-0615-0694 No Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Vahideh Behmard وحیده بهمرد Vahideh.behmard@gmail.com 0000-0002-2179-9902 No Student Research Committee, Department of Midwifery, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran Student Research Committee, Department of Midwifery, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran Mehri Fallah Raoufi مهری فلاح رﯮفی mraufi6@gmail.com No Department of Clinical Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Department of Clinical Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Elnaz Sadat Mousavi Sadr Jadidi الناز سادات موسوی صدر جدیدی Elnazsadat64@gmail.com 0000-0003-4270-2046 No Department of Basic Sciences, Payame Noor University, Tehran, Iran Department of Basic Sciences, Payame Noor University, Tehran, Iran Elham Rostami الهام رستمی elhamrostami23@yahoo.com 0000-0003-4275-0237 No Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran Rahil Norbakhsh راحیل نوربخش rahilnorbakhsh@yahoo.com No Department of Virology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Department of Virology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Vajiheh Najafi وجیهه نجفی v.najafi2013@gmail.com No Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran Tohid Moradi Gardeshi توحید مرادی گردشی d.tohidmoradi@iau-garmsar.ac.ir 0000-0002-3366-0211 No Department of Veterinary Sciences, Garmsar Branch, Islamic Azad University, Garmsar, Iran Department of Veterinary Sciences, Garmsar Branch, Islamic Azad University, Garmsar, Iran Fahimeh Safizadeh فهیمه صفی زاده FahimeSafizade67@gmail.com No Iranian Social Security Organization, Kerman, Iran Iranian Social Security Organization, Kerman, Iran Haleh Barmaki هاله برمکی halehbarmaki1400@gmail.com 0000-0003-3829-9952 Yes Department of Laboratory Medicine, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Department of Laboratory Medicine, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran