International Journal of Medical Laboratory
مجله بین المللی علوم آزمایشگاهی
IJML
Medical Sciences
http://ijml.ssu.ac.ir
1
admin
2423-3706
2423-3714
en
jalali
1401
12
1
gregorian
2023
3
1
10
1
online
1
fulltext
en
ارزیابی پارامترهای هماتولوژی و بیوشیمیایی در بیماران تالاسمی ماژور شهر بوشهر
Hematological and Biochemical Parameters of β-Thalassemia Major Patients in Bushehr City: A Comparative Analysis
خون شناسی و بانک خون
Hematology & Blood Banking
پژوهشي
Research
<span style="font-size:11pt"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">زمینه و هدف</span></span></span></b></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> بتا تالاسمی گروهی از اختلات هموگلوبینی است که فرم هموزیگوت آن به عنوان تالاسمی ماژور بتا شناخته میشود. </span></span></span><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">هدف از این مطالعه ارزیابی پارامترهای هماتولوژی و بیوشیمیایی در بیماران تالاسمی ماژور شهر بوشهر میباشد.</span></span></span><b><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:"B Nazanin""></span></span></span></b></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">مواد و روش ها</span></span></span></b><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">در این مطالعه 94 بیمار تالاسمی ماژور بتا با 94 </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">فرد</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> سالم (کنترل) مقایسه شد. ارزیابیهای هماتولوژی شامل</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Hb </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Hct</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">MCV</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">،</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> MCH </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> و </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">MCHC</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">بودند. پارامترهای بیوشیمیایی شامل تست</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">های عملکرد کلیه، کبد، تیروئید، پروفایل لیپیدی، آلبومین</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">(Alb)</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، سدیم</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">(Na)</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> ، پتاسیم</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">(K)</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، کلسیم</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">(Ca)</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، فسفر</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">(Ph)</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، قند خون ناشتا</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">(FBS)</span></span></span><span style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> و فریتین سرم بود.</span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b> </b><b> </b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">نتایج</span></span></span></span></b><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">در بیماران تمام پارامترهای هماتولوژی</span></span></span> <span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Hb</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">،</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Hct </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">MCH </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">و</span></span></span> <span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">MCV</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">در مقایسه با گروه کنترل کاهش معنیداری داشتند </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">(P<0.05)</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> به جز </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">MCHC</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> که تفاوت ناچیزی با گروه کنترل داشت</span></span></span> <span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">(P>0.05)</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">. سطح سرمی </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">TG</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Ph</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">FBS</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">AST</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">ALT</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">ALP</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، </span></span></span> <span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">UA</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">و </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> Bili</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">دربیماران مقایسه با گروه کنترل بالاتر بود و سطح سرمی کلسترول (</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Chol</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">)، لیپوپروتئین با چگالی بالا (</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">HDL</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">) و لیپوپروتئین با تراکم پایین (</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">LDL</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">) در بیماران در مقایسه با گروه کنترل پایینتر بود</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">(P<0.05)</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">. بین سطح سرمی </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Na</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">،</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">K </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Ca</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> و </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Alb</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> در بیماران در مقایسه با گروه کنترل تفاوت معناداری مشاهده نشد. شیوع هایپوتیروئیدیسم اولیه 5.31% گزارش شد.</span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">نتیجه گیری</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> این مطالعه تاکید میکند که پیگیری و ارزیابی منظم بیماران تالاسمی ماژور میتواند پروتکل های درمانی را بهبود ببخشد.</span></span></span></span></span></span></span></span><br>
<div style="text-align: justify;"><span style="font-size:12pt"><span style="line-height:115%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:115%">Background and Aims:</span></span></b><b> </b><span adobe="" class="A3" garamond="" pro="" style="font-family:"><span style="color:black"><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">β</span></span></span></span></span><span style="font-size:10.0pt"><span style="line-height:115%">-thalassemia is the most common genetic disorder worldwide. β-thalassemia major results in severe anemia and serious complications. So, this study aims to evaluate the hematological and biochemical markers in </span></span><span adobe="" class="A3" garamond="" pro="" style="font-family:"><span style="color:black"><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">β</span></span></span></span></span><span style="font-size:10.0pt"><span style="line-height:115%">-thalassemia major patients in Bushehr city.</span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"><b><span style="font-size:10.0pt"><span style="line-height:115%">Materials and Methods</span></span></b><span style="font-size:10.0pt"><span style="line-height:115%">: Our study included 94 transfusion-dependent </span></span><span adobe="" class="A3" garamond="" pro="" style="font-family:"><span style="color:black"><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">β</span></span></span></span></span><span style="font-size:10.0pt"><span style="line-height:115%">-thalassemia major were compared with 94 normal healthy subjects as controls. Hematological assessments included complete blood count indices. The biochemical evaluations included liver, kidney, and thyroid function tests, lipid profile, sodium, potassium, calcium, phosphorus, fasting blood sugar, and serum ferritin.</span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:115%">Results:</span></span></b><span style="font-size:10.0pt"><span style="line-height:115%"> <span style="color:black">All hematological parameters in patients, such as hemoglobin (p < 0.01), hematocrit (p < 0.01), mean corpuscular volume (p < 0.05), and mean corpuscular hemoglobin (p <0.05), were significantly reduced compared to the control group except mean corpuscular hemoglobin concentration which was insignificant (p</span> > </span></span><span style="font-size:10.0pt"><span style="line-height:115%">0.05). </span></span><span style="font-size:10.0pt"><span style="line-height:115%">Higher levels of <span style="color:black">triglyceride,</span> <span style="color:black">phosphorus,</span> fasting blood sugar, <span style="color:black">aspartate aminotransferase, alanine transaminase, alkaline phosphatase, uric acid, total and direct bilirubin, </span>and lower levels of <span style="color:black">cholesterol, high-density lipoprotein, and low-density lipoprotein</span> <span style="color:black">were observed </span>in patients in comparison to the control group (<span style="color:black">p < 0.05</span>). Serum sodium, potassium, calcium, and albumin was not significantly different from the control group (p > 0.05). The prevalence of primary hypothyroidism (thyroid stimulating hormone > 4.5 mIU/l and T4 < 5.6 μg/dl) was reported at 5.31%.</span></span> <span dir="RTL" lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"></span></span></span></span></span><br>
<b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusions</span></span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">: This study emphasized the necessity for regular follow-up and evaluation of </span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">β-thalassemia<span style="color:black">, which could be used to improve treatment protocols.</span></span></span></div>
اضافهبار آهن, بتا تالاسمی ماژور, پارامترهای بیوشیمیایی
Hematological characteristics,Iron overload,Serum ferritin, β-thalassemia major
57
66
http://ijml.ssu.ac.ir/browse.php?a_code=A-10-497-1&slc_lang=en&sid=1
zeynab
gharehdaghi
زینب
قره داغی
z.gharehdaghi1993@gmail.com