en خون شناسی و بانک خون Hematology & Blood Banking پژوهشي Research <div style="text-align: justify;"><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:115%">Background and Aims: </span></span></b><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%">Glucose-6-phosphate dehydrogenase (G6PD) deficiency is humans&rsquo; most common erythrocyte enzyme defect</span></span></span><span style="font-size:10.0pt"><span style="line-height:115%">. About 400 million people are estimated to be affected by this disorder worldwide. Antimalarial drugs, especially primaquine, and other oxidative stress, can cause hemolytic complications in G6PD deficient individuals. This study aimed to evaluate the prevalence of G6PD deficiency in Kerman City in southern Iran. </span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:115%">Materials and Methods:</span></span></b><span style="font-size:10.0pt"><span style="line-height:115%"> This descriptive cross-sectional study was conducted from 2016 to 2021. Blood samples were taken from all patients with symptoms of G6PD deficiency who were referred to a general hospital in Kerman City in southern Iran. The G6PD enzyme activity was measured qualitatively by fluorescent spot test. </span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:115%">Results:</span></span></b><span style="font-size:10.0pt"><span style="line-height:115%"> A total of 6369 patients were included in this study. G6PD deficiency was seen in 424 (6.7%) subjects. Of 424 patients, 359 (84.7%) were severely G6PD deficient, and 65 (15.3%) patients exhibited partial deficiency. G6PD deficiency was seen in 324 (9.3%) males and 100 (3.4%) females (p < 0.001).</span></span></span></span></span><br> <b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Conclusion</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">:<i> </i>The results of our study confirmed the existence of G6PD deficiency in a significant percentage of patients in Kerman City. Therefore, many people in this city are exposed to hemolytic complications if they use antimalarial drugs and other oxidative substances. According to our results, testing G6PD deficiency and monitoring the potential primaquine toxicity in patients who receive primaquine are highly recommended.</span></span></div> Deficiency, Favism, G6PD, Kerman, Iran 173 178 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-422-5&slc_lang=en&sid=1 Mohadeseh Kamali محدثه کمالی mohadesehkamali.mk@gmail.com No Department of Internal Medicine, Faculty of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran گروه بیماری های داخلی، دانشکده پزشکی، دانشگاه علوم پزشکی جیرفت، جیرفت، ایران Mehdi Taheri Sarvtin مهدی طاهری سروتین mehditaheri.mt@gmail.com 0000-0003-3600-9472 Yes Department of Medical Mycology and Parasitology, Faculty of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran گروه قارچ شناسی و انگل شناسی، دانشکده پزشکی، دانشگاه علوم پزشکی جیرفت، جیرفت، ایران