International Journal of Medical Laboratory
مجله بین المللی علوم آزمایشگاهی
IJML
Medical Sciences
http://ijml.ssu.ac.ir
1
admin
2423-3706
2423-3714
en
jalali
1402
11
1
gregorian
2024
2
1
11
1
online
1
fulltext
en
The Oncogenic Potential of IQ Motif-Containing GTPase-Activating Protein3 in Human Bladder Cancer: An In-Silico Analysis
بیوشیمی
Biochemistry
پژوهشي
Research
<div style="text-align: justify;"><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%"><span style="color:black">Introduction: </span></span></span></span></b><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%"><span style="color:black">IQ motif-containing GTPase-activating protein3 (IQGAP3) contributes to the progression of bladder urothelial carcinoma (BLCA), but its mechanisms are not systematically specified. Due to the oncogenic potential of IQGAP3, the current <i>in-silico</i> study intended to elucidate IQGAP3's role in BLCA progression.</span></span></span></span><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%"></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%"><span style="color:black">Materials and Methods: </span></span></span></span></b><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%"><span style="color:black">Many<b> </b>bioinformatics tools, including UALCAN, Kaplan–Meier plotter, TNMplot, cBioPortal, GeneMania, Enrichr, TIMER2, muTarget, and UCSC Xena, were applied in the current study.</span></span></span></span><span dir="RTL" lang="FA" style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%"></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%"><span style="color:black">Results: </span></span></span></span></b><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%"><span style="color:black">The <i>IQGAP3</i> level was more pronouncedly raised in BLCA tissues than in normal bladder tissues, and its increased expression was related to the advanced stage and higher grade. Enhanced IQGAP3 expression could result from its genetic alteration. Moreover, the mutation in <i>P53</i> and <i>RB1</i> genes was robustly associated with increased <i>IQGAP3</i> expression. Besides, <i>IQGAP3 </i>correlative genes were dominantly involved in the cell cycle. On the other hand, <i>IQGAP3</i> upregulation influenced immune checkpoint levels in the tumor microenvironment. </span></span></span></span><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%"></span></span></span></span></span></span><br>
<b><span style="font-size:10.0pt"><span style="background:white"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion: </span></span></span></span></b><span style="font-size:10.0pt"><span style="background:white"><span new="" roman="" style="font-family:" times=""><span style="color:black">The <i>in-silico</i> findings suggested that <i>IQGAP3</i> overexpression could be a crucial biomarker in BLCA.</span></span></span></span></div>
Bioinformatics, Bladder cancer, IQGAP3, Oncogene
28
44
http://ijml.ssu.ac.ir/browse.php?a_code=A-10-527-1&slc_lang=en&sid=1
Omid
Abazari
امید
اباذری
omid.abz1990@gmail.com