en عمومى General پژوهشي Research <div style="text-align: justify;"><span style="font-size:16px;"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="line-height:115%">Introduction:</span></b><span style="line-height:115%"> Sports training has been shown to have a positive impact on conditions such as dementia, but its exact mechanisms remain unclear. The present study aimed to determine the effects of pre-training with endurance and cognitive endurance training on brain-derived neurotrophic factor levels in aged rats after dementia.</span></span></span><br> <span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="line-height:115%">Materials and Methods:</span></b><span style="line-height:115%"> Male Wistar rats were randomly divided into 4 groups of 10. These groups included the healthy control group, the dementia group, the dementia group with endurance training, and the dementia group with cognitive-endurance training. Trihexyphenidyl was used to create a mouse model of dementia. Swimming and the Morris water maze were considered for endurance and cognitive endurance training, respectively. After the training period, the expression level of brain-derived neurotrophic factor was measured using the Real-Time polymerase chain reaction.</span></span></span><br> <span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="line-height:115%">Results: </span></b><span style="line-height:115%">Brain-derived neurotrophic factor expression is significantly decreased in rats with dementia compared to control rats. Exercise had a positive effect on brain-derived neurotrophic factor expression (p<0.05). Cognitive- endurance exercise was found to be more effective than endurance exercise.</span></span></span><br> <b><span new="" roman="" style="font-family:" times="">Conclusion:</span></b><span new="" roman="" style="font-family:" times=""> Endurance and cognitive-endurance exercises can be considered suitable strategies for preventing dementia in the elderly and also for reducing the complications of dementia in affected people.</span></span></div> Brain-derived neurotrophic factor, Cognitive-endurance exercise, Dementia, Endurance exercise, Exercise 31 40 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-531-1&slc_lang=en&sid=1 Alireza Daneshvar علیرضا دانشور adaneshvar21@yahoo.com No Department of Sports Sciences, Boj.C., Islamic Azad University, Bojnord, Iran Department of Sports Sciences,Boj.C., Islamic Azad University, Bojnord, Iran Mostafa Teymuri Kheravi مصطفی تیموری خروی m.tymuri3@gmail.com Yes Department of Sports Sciences, Boj.C., Islamic Azad University, Bojnord, Iran Department of Sports Sciences, Boj.C., Islamic Azad University, Bojnord, Iran Mehdi Mohsenzadeh مهدی محسن زاده mohsenmehdi@gmail.com No Gerash University of Medical Sciences, Gerash, Iran Gerash University of Medical Sciences, Gerash, Iran Najmeh-Alsadat Shojaeian نجمه السادات شجاعیان nshojaeian@yahoo.com No Department of Sports Sciences, Boj.C., Islamic Azad University, Bojnord, Iran Department of Sports Sciences, Boj.C., Islamic Azad University, Bojnord, Iran Bahram Abedi بهرام عابدی No Department of Exercise Physiology, NT.C., Islamic Azad University, Tehran, Iran Department of Exercise Physiology, NT.C., Islamic Azad University, Tehran, Iran