en درگیری کبد در سرطان های کودکان: بینش های بالینی و آزمایشگاهی عمومى General پژوهشي Research <div style="text-align: justify;"><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:115%">Introduction:</span></span></b><span style="font-size:10.0pt"><span style="line-height:115%"> <span style="background:white"><span style="color:black">Liver involvement is observed in various malignancies and is characterized by abnormal liver function tests, imaging findings, or clinical signs linked to the liver. This study aimed to evaluate hepatic manifestations in childhood malignancies.</span></span><span style="background:white"></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%"><span style="color:black">Materials and Methods:</span></span></span></span></b><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%"><span style="color:black"> This cross-sectional descriptive study analyzed hepatic manifestations in children under 18 with malignancy admitted to the pediatric oncology ward between April 2016 and April 2020.</span></span></span></span><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%"></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%"><span style="color:black">Results:</span></span></span></span></b><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%"><span style="color:black"> Among the 130 patients studied, 82 (63%) were male, and 48 (37%) were female. The mean age was 5.9 &plusmn; 4.31 years. Patients with hepatoblastoma, lymphoma, and leukemia exhibited the highest rates of abnormal liver enzyme levels. Elevated aspartate aminotransferase &nbsp;levels were most frequently noted in patients with hepatoblastoma (83.3%), non-Hodgkin&rsquo;s lymphoma (58.3%), and acute lymphoblastic leukemia (32.7%). Similarly, elevated alanine aminotransferase levels were highest in patients with hepatoblastoma (50%), Hodgkin&rsquo;s lymphoma (16.7%), and acute myeloblastic leukemia (22.2%). Hepatomegaly was the most common liver-related clinical sign, occurring in 41.5% of patients.</span></span></span></span><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:115%"></span></span></span></span></span></span><br> <b><span style="font-size:10.0pt"><span style="background:white"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion:</span></span></span></span></b><span style="font-size:10.0pt"><span style="background:white"><span new="" roman="" style="font-family:" times=""><span style="color:black"> The findings indicate that clinical and laboratory liver involvement is highly prevalent among children with malignancies. Such involvement can provide insights into disease progression and play a critical role in treatment planning.</span></span></span></span></div> Childhood cancer, Hematologic malignancy, Hepatic manifestations, Liver involvement 146 151 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-541-1&slc_lang=en&sid=1 Ghasem Miri-Aliabad قاسم میری علی اباد ghmiri1357@gmail.com Yes Department of Pediatrics, Ali Asghar Children’s Hospital, Iran University of Medical Sciences, Tehran, Iran Department of Pediatrics, Ali Asghar Children’s Hospital, Iran University of Medical Sciences, Tehran, Iran Hossein Ali Khazaei حسینعلی خراعی h_khazaei118@yahoo.com No Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Seyed Mohammad Nasiraldin Tabatabaei سیدمحمدنصیرالدین طباطبایی mttaba89@gmail.com No Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Ali Khajeh علی خواجه dr_khajehneuro@gmail.com No Children and Adolescents Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Children and Adolescents Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Zeinab Nasri Nasrabadi زینب نصری نصرابادی zeinab_nasrinasrabadi@yahoo.com No Department of Pediatrics, Ali Asghar Children’s Hospital, Iran University of Medical Sciences, Tehran, Iran Department of Pediatrics, Ali Asghar Children’s Hospital, Iran University of Medical Sciences, Tehran, Iran Reyhaneh Rezvani Kharashadizadeh ریحانه رضوانی خراشادی زاده reyhanehr.1371@yahoo.com No Zahedan University of Medical Sciences, Zahedan, Iran