en ایمنی شناسی Immunology پژوهشي Research <div style="text-align: justify;"><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="font-size:9.0pt"><span style="line-height:115%">T</span></span><span style="font-size:10.0pt"><span style="line-height:115%">-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy induced by the proliferation of immature T-cell precursors. Even with the development of multi-agent chemotherapy, treatment failure, and relapse remain the most important challenges because of drug resistance. miRNAs are a class of small non-coding RNAs that modulate the expression of target mRNAs at the post-transcription level. They play significant roles in many biological processes, including tumorigenesis, differentiation, and apoptosis. Recent research has underlined the contribution of specific miRNAs to the pathogenesis of T-ALL and drug resistance. In the present review, the therapeutic potential of miRNA modulation in T-ALL disease will be discussed according to their role in disease biology, mechanisms of resistance, and possible strategies for clinical application.</span></span></span></span></span></div> microRNAs, T-cell Acute Lymphoblastic Leukemia, Treatment Response 101 116 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-55-4&slc_lang=en&sid=1 Kaveh Tari کاوه طاری k.tari@modares.ac.ir No Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Pooya Valizadeh Ardalan پویا ولی زاده اردلان pooya@modares.ac.ir No Graduate Student in Biomedical Sciences, Faculty of Natural Sciences, Bonn- Rhein Sieg University of Applied Sciences, Bonn, Germany Graduate Student in Biomedical Sciences, Faculty of Natural Sciences, Bonn- Rhein Sieg University of Applied Sciences, Bonn, Germany Narges Ghasemi Mehr نرگس قاسمی مهر No Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Arshia Daraei ارشیا دارایی No Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Saied Abroun سعید ابرون abroun@modares.ac.ir Yes Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran