en خون شناسی و بانک خون Hematology & Blood Banking پژوهشي Research <p style="text-align: justify;"><span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><b>Introduction:</b> The Torque Teno Virus (TTV) can be transmitted through blood and blood products such as coagulation factors. People with haematological disorders, such as thalassemia patients, may be exposed to the pathological consequences of this virus. This study aims to determine how prevalent this viral pathogen is in individuals with thalassemia.<br> <b><span lang="EN">Materials and Methods:</span></b><span lang="EN"> In this cross-sectional study, serum samples were collected from 99 patients with thalassemia from a special disease center in Yazd city between August and September 2015.</span> <span lang="EN">A Roche (Germany) DNA extraction kit extracted the genome from the patient&#39;s serum. Finally, the presence of the TTV genome was evaluated by a Nested polymerase chain reaction test.</span><br> <b><span lang="EN">Results:</span></b><span lang="EN"> The data obtained from the molecular method revealed that the serum of 43 people with thalassemia was infected with TTV, among which 22 cases were observed in women and 21 cases in men (p = 0.525). The patients were significantly younger than 30. The frequency of TTV in thalassemia patients was not significantly affected by other parameters, such as gender, length of blood transfusion, and history of hepatitis C infection. </span><br> <b><span lang="EN">Conclusion:</span></b><span lang="EN"> The data obtained from the present study confirmed the significant presence of the TTV virus in thalassemia patients, which can impact preventive measures and health programs in patients with blood disorders receiving blood factors.</span></span></span></span><span lang="EN" style="font-size:14.0pt"><span style="line-height:107%"><span calibri="" style="font-family:"> </span></span></span></p> Frequency, Thalassemia, Torque teno virus, Yazd 244 250 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-116-2&slc_lang=en&sid=1 Javad Charostad جواد چاراستاد astani_irr@yahoo.com No Department of Microbiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Microbiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mahdieh Abdollahi مهدیه عبداللهی astani_irrr@yahoo.com No Department of Microbiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Microbiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Fatemeh Akhavan Tafti فاطمه اخوان تفتی astani_irrrr@yahoo.com No Yazd Blood Transfusion Center, Yazd, Iran Yazd Blood Transfusion Center,Yazd, Iran Naghi Taghvai نقی تقوی astanii_ir@yahoo.com No Yazd Blood Transfusion Center, Yazd, Iran Yazd Blood Transfusion Center,Yazd, Iran Hayedeh Javad Zadeh Shahshahani هایده جوادزاده شهشهانی astaniii_ir@yahoo.com No Yazd Blood Transfusion Center, Yazd, Iran Yazd Blood Transfusion Center,Yazd, Iran Akram Astani اکرم آستانی astani_ir@yahoo.com Yes Department of Microbiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Microbiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran