International Journal of Medical Laboratory

en The Effect of Moderate-Intensity Aerobic Exercise on IL-8, IL-1β, and NFκB Levels in Women with Type 2 Diabetes بیوشیمی Biochemistry پژوهشي Research <div style="text-align: justify;">Introduction: Type 2 diabetes is one of the most common chronic metabolic diseases and is associated with increased inflammatory markers. The present study aimed to investigate the effect of moderate-intensity aerobic exercise on interleukin (IL)-8, IL-1β, and nuclear factor kappa B (NFκB) levels in women with type 2 diabetes. Materials and Methods: This semi-experimental study employed a pretest-posttest design with a control group. Thirty women aged 40 to 50 years with at least three years of diagnosed type 2 diabetes were purposefully selected and randomly assigned to either an exercise group or a control group (n = 15 per group). The exercise group participated in an 8-week progressive aerobic training program (three sessions per week) at 35-75% of maximum heart rate. IL-8 and IL-1β levels were measured using the enzyme-linked immunosorbent assay method, and NFκB activity was assessed through western blot analysis from blood serum samples. Results: The findings indicated a significant decrease in IL-8 and IL-1β levels, and in NFκB activity, in the exercise group compared to the control group after the intervention (p < 0.001). This reduction was statistically significant both within the exercise group compared to the pretest and compared with the control group. Conclusion: This study demonstrates that moderate-intensity aerobic exercise significantly reduces inflammatory markers in women with type 2 diabetes. It appears that aerobic exercise may be recommended as an effective non-pharmacological approach to improve inflammatory status and assist in the management of type 2 diabetes. </div> Aerobic exercise, IL-1β, IL-8, NFκB, Type 2 diabetes 67 78 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-567-2&slc_lang=en&sid=1 Alireza Babaei Mazreno علیرضا بابایی مزرعه نو ft.taghian@gmail.com No Department of Sports Physiology, Isf.C., Islamic Azad University, Isfahan, Iran Department of Sports Physiology, Isf.C., Islamic Azad University, Isfahan, Iran Farzaneh Taghian فرزانه تقیان ft.taghiann@gmail.com Yes Department of Sports Physiology, Isf.C., Islamic Azad University, Isfahan, Iran Department of Sports Physiology, Isf.C., Islamic Azad University, Isfahan, Iran Khosro Jalali Dehkordi خسرو جلالی دهکردی ft.taghiannn@gmail.com No Department of Sports Physiology, Isf.C., Islamic Azad University, Isfahan, Iran Department of Sports Physiology, Isf.C., Islamic Azad University, Isfahan, Iran Esmaeil Babaei اسماعیل بابایی ft.taghiannnn@gmail.com No Faculty of Ophthalmology, Faculty of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran Faculty of Ophthalmology, Faculty of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran