International Journal of Medical Laboratory

en Appendiceal Mucinous Neoplasms and Peritoneal Spread: A Decade of Clinical Experience from Two Tertiary Hospitals in Yazd آسیب شناسی Pathology پژوهشي Research Introduction: Appendiceal mucinous neoplasms (AMNs) are rare tumors. They range from benign cystadenomas to malignant mucinous adenocarcinomas, with potential for peritoneal spread and recurrence, particularly in high-grade or ruptured lesions. Materials and Methods: This retrospective cross-sectional study aimed to determine the clinicopathologic features in patients with AMNs at Shahid Sadoughi and Shahid Rahnemon Hospitals (2014-2024). Inclusion required both appendiceal and peritoneal pathology specimens. Data were collected from medical records and follow-up interviews, and statistical analysis was performed using the Pearson Chi-square test. Results: Fifty-seven patients (39 females, 18 males; mean age: 51.26 ± 16.09 years) were included, with the highest incidence in the 50–69 age group (63%). Abdominal pain was the most common symptom (78.9%), followed by a palpable mass (21.1%). Histologically, 68.4% had low-grade appendiceal mucinous neoplasms (LAMN), 21% mucinous adenocarcinoma. Peritoneal metastasis was seen in 47.4%, overall 75% of adenocarcinomas, 46.2% of LAMNs, and none in cystadenomas. Tumor recurrence occurred in six patients (10.5%), 7.7% of LAMN and 25% of mucinous adenocarcinoma of the appendix. No significant associations were found between tumor type or size and recurrence/metastasis. Three deaths (5.3%) were reported; overall survival was 94.7%. Conclusions: LAMN was the most prevalent AMN subtype, typically with favorable outcomes despite frequent (46.2%) peritoneal involvement. The survival rate in LAMN was 92.3%, with one death reported in a patient with a tumor size of 5-10 cm, while no deaths were reported in mucinous adenocarcinoma of the appendices. Further studies with larger cohorts are needed to clarify prognostic factors and guide management. Adenocarcinoma mucinous, Appendiceal neoplasms, Cross-sectional study, Neoplasms 51 58 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-575-1&slc_lang=en&sid=1 Maryam Ali Panah مریم علی پناه maryamvajihinejadd@gmail.com No Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Majid Entezari مجید انتظاری maryamvajihinejaddd@gmail.com No Department of Surgery, Research Development Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Surgery, Research Development Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Maryam Vajihinejad مریم وجیهی نژاد maryamvajihinejad@gmail.com Yes Department of Pathology, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Pathology, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran