en ایمنی شناسی Immunology پژوهشي Research <p><strong>Background and Aims:</strong> <em>Aspergillus fumigatus</em> is a sporadic fungus that causes different infections and allergies in immunocompromised patients. The allergic disease caused by this fungus is called allergic bronchopulmonary aspergillosis (ABPA). ABPA is considred important in atopic and immunocompromised individuals, which can result in inflammation and epithelial damage. Therefore, the aim of this study was to evaluate the T helper (Th)2 responses in a ABPA murine model by measuring the main cytokines involved in Th2.</p> <p><strong>Materials and Methods</strong><strong>:</strong> Twenty male BALB/c mice were divided into two groups of 10 mice each: control and ABPA group. ABPA was induced by inhalation of <em>A. fumigatus </em>conidia intranasally. Total and specific IgE were measured in the mice sera. Levels of cytokines in broncho alveolar lavage (BAL) of under studied &nbsp;groups were measured by Enzyme-linked immunosorbent assay three weeks after the treatment.</p> <p><strong>Results</strong><strong>:</strong> The obtained results indicated that total and specific IgE increased in the ABPA group (p<0.05). The levels of Interleukin (IL)-4, IL-5 and IL-13 in brocho alveolar lavage of ABPA group was significantly higher than the control group (p<0.05), whereas interferon-gamma levels did not reveal any significant differences between the studied groups<strong>.</strong></p> <p><strong>Conclusions</strong>: The findings of the present study confirmed the role of Th2 cytokines in the ABPA reactions. However, more comprehensive studies are necessitated to determine the exact mechanisms of immune responses to ABPA as well as the role of Th1/Th2 responses in control of ABPA reactions. Regulation of Th2 responses could be regarded as a potential therapy for ABPA as well.&nbsp;</p> سایتو کاین Allergic Bronchopulmonary, Aspergillus fumigatus, Interleukin, Murine model, Th2 response 151 157 http://ijml.ssu.ac.ir/browse.php?a_code=A-10-67-1&slc_lang=en&sid=1 Donya Nikaein m_taghavi@ut.ac.ir No Academic Center for Education, Culture and Research (ACECR), University of Tehran, Tehran, Iran. Alireza Khosravi m_taghavi@ut.ac.ir No Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Seyyed Shamsadin Athari m_taghavi@ut.ac.ir No Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Abdolghaffar Ownagh m_taghavi@ut.ac.ir No Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Mehdi Taghavi m_taghavi@ut.ac.ir Yes Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.