A Review of Tissue‐Engineered Cartilage Utilizing Fibrin and Its Composite

Pourentezari, Majid; Anvari, Morteza; Yadegari, Maryam; Abbasi, Abolghasem; Dortaj, Hengameh

doi:10.18502/ijml.v8i1.5665

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Volume 8, Issue 1 (February 2021) IJML 2021, 8(1): 1-9 | Back to browse issues page

‎ 10.18502/ijml.v8i1.5665

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Pourentezari M, Anvari M, Yadegari M, Abbasi A, Dortaj H. A Review of Tissue‐Engineered Cartilage Utilizing Fibrin and Its Composite. IJML 2021; 8 (1) :1-9
URL: http://ijml.ssu.ac.ir/article-1-370-en.html

A Review of Tissue‐Engineered Cartilage Utilizing Fibrin and Its Composite

Majid Pourentezari

, Morteza Anvari

, Maryam Yadegari

, Abolghasem Abbasi

, Hengameh Dortaj ^*

Department of Tissue Engineering and Applied Cell Science, Shiraz University of Applied Medical Science and Technologies, Shiraz, Iran

Abstract: (727 Views)

Suitable alternatives are made for damaged or diseased organs and tissues in tissue engineering by combining cellular and molecular biology with materials and mechanical engineering. Fibrin is a critical blood component responsible for homeostasis, used extensively as a biopolymer scaffold in tissue engineering. This study summarizes the latest developments in organ and tissue regeneration using fibrin as a scaffold material. The combination of active peptides and growth factors through a heparin-bound delivery system improves fibrin function as a scaffold. Besides, the development of fibrin precursors as recombinant proteins solves multiple or single donor fibrin adhesives. Its composite allows biomolecules to be combined with fibrin and can significantly enhance fibrin efficacy in cartilage tissue engineering applications.

Keywords: Fibrin, Fibrinogen, Fibrin Composite, Cartilage, Scaffold