Write your message
Volume 2, Issue 1 (May 2015)                   IJML 2015, 2(1): 34-40 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kooshyar M M, Sadeghian M H, Keramati M R, Rahimi H, Shams S F, Shakeri S et al . Frequency of FLT3 ITD and FLT3 TKD Mutations in Multiple Myeloma Patients (A Case Control Study). IJML. 2015; 2 (1) :34-40
URL: http://ijml.ssu.ac.ir/article-1-42-en.html
Department of Hematology and Blood Banking, Cancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract:   (3675 Views)

Background and Aims: Multiple myeloma is a malignant proliferation of plasma cells derived from a single clone. The tumor, its products and the host response lead to organ damages. Some factors that are responsible in its pathogenesis are recognized. As FMS like Tyrosine Kinase 3 receptor (FLT3) mutation has been proved as a determining factor in leukemic patients the goal of this study was to find association of FLT3 internal tandem duplication (ITD) and FLT3 tyrosine kinase domain (TKD), mutations with multiple myeloma.

Materials and Methods: This case-control study was conducted on 60 paraffin-embedded bone marrow biopsies (30 multiple myeloma and 30 normal bone marrow specimens) in the pathology departments of Ghaem and Imam Reza hospitals in Mashhad. After sections preparation, DNA was extracted and two PCR reactions were set up for detection of FLT3/ ITD and FLT3/TKD mutations.

Results: The Mean age of samples was 64±10 years. No FLT3 mutations were detected in multiple myeloma patients.

Conclusions: Our findings showed that FLT3 mutations occurrence seem unusual in multiple myeloma.

Full-Text [PDF 594 kb]   (998 Downloads)    
Type of Study: Research | Subject: General
Received: 2015/05/11 | Accepted: 2015/05/11 | Published: 2015/05/11

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | International Journal of Medical Laboratory

Designed & Developed by : Yektaweb