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Volume 3, Issue 3 (August 2016)                   IJML 2016, 3(3): 185-190 | Back to browse issues page

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Ataei M, Farashahi E, Seifati M, Ghasemi N. Frequency of Polymorphism Alu Insertion in Progesterone Receptor Gene in Endometriosis. IJML 2016; 3 (3) :185-190
URL: http://ijml.ssu.ac.ir/article-1-131-en.html
Frequency of Polymorphism Alu Insertion in Progesterone Receptor Gene in Endometriosis
Mohammad Ataei , Ehsan Farashahi , Morteza Seifati , Nasrin Ghasemi *
Recurrent Abortion Research Centre, Reproductive Sciences Institute, Shahid Sadoughi University of Medicinal Sciences, Yazd, Iran.
Abstract:   (2577 Views)

Background and Aims: This research aimed to study a possible link between endometriosis and polymorphism of the progesterone receptor gene.

Materials and Methods: The control group consisted of 86 women without endometriosis and the case group comprised 86 patients with a diagnosis of endometriosis by laparoscopy. Genotypes for Alu insertion polymorphisms (A1/A1, A1/A2 and A2/A2) were described by polymerase chain reaction and determined on a 2% agarousegel.

Results: The genotype frequencies of A1/A2 and A2/A2 were not significantly higher in patients than in the control group without endometriosis. On the other hand differences in the Alu insertion polymorphism frequencies were not significant.

Conclusion: According to our investigations, we conclude that there is not a significant correlation between Alu insertion polymorphism and endometriosis. ;line-height:115%'> According to our investigations, we conclude that there is not a significant correlation between Alu insertion polymorphism and endometriosis.

Keywords: Endometriosis, Polymerase chain reaction, Progesterone receptor gene
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Type of Study: Research | Subject: Genetics/ Biotechnology
Received: 2016/11/13 | Accepted: 2016/11/13 | Published: 2016/11/13
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