Write your message
Volume 4, Issue 3 (August 2017)                   IJML 2017, 4(3): 201-210 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Jalali M, Hassanipour M, Hajizadeh M, Khanamani Falahati Pour S, Khoshdel A, Roustai F, et al . Troxerutin Chronic Treatment Protects against Fructose-induced Metabolic Syndrome in Male Rats. IJML. 2017; 4 (3) :201-210
URL: http://ijml.ssu.ac.ir/article-1-195-en.html
Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Abstract:   (1929 Views)
Background and Aims: Metabolic syndrome, a common metabolic disorder, for the serious health consequences such as insulin resistance and lipid abnormalities has been considered as a major clinical challenge with obscure causes. Oxidative stress is an important component of metabolic syndrome, contributing in its development. Troxerutin, a semi-synthetic derivative of natural bioflavonoid rutin, exerts various pharmacological activities, which among all, strong anti-oxidative property is of great importance. The aim of the current study was to evaluate the effects of troxerutin on metabolic parameters and oxidative stress in metabolic syndrome induced by fructose in male rats.
Materials and Methods: In order to induce metabolic syndrome, animals received the water containing 20% fructose for 8 weeks. Troxerutin was administered to animals with the dose of 150 mg/kg orally for 4 weeks after induction of metabolic syndrome following biochemical analysis and oxidative stress marker assessment.
Results: Data showed that high-fructose diet leads to elevation of blood glucose and insulin resistance and causes abnormalities in lipid profile as well as oxidative stress enhancement (signs of a metabolic syndrome) (p<0.001). Troxerutin administration improved the detrimental effects of metabolic syndrome on biochemical factors and diminished oxidative stress (p<0.001).
Conclusions: Troxerutin administration reverses the deleterious effect of metabolic syndrome in rats with high-fructose diet.
Full-Text [PDF 480 kb]   (965 Downloads)    
Type of Study: Research | Subject: Biochemistry
Received: 2017/08/30 | Accepted: 2017/08/30 | Published: 2017/08/30

Add your comments about this article : Your username or Email:

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | International Journal of Medical Laboratory

Designed & Developed by : Yektaweb