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Volume 9, Issue 1 (February 2022)                   IJML 2022, 9(1): 47-54 | Back to browse issues page

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R A, AB A, S S, Gupta D. A Root Cause Analysis of Haemolysis Encountered in Leuco-filtration of Stored Packed Red Cells Units. IJML. 2022; 9 (1) :47-54
URL: http://ijml.ssu.ac.ir/article-1-428-en.html
Department of Transfusion Medicine, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
Abstract:   (156 Views)
Background and Aims: Leukoreduction of blood components has reduced the incidence of transfusion-associated adverse events. Leucofiltration is the most effective method of leukoreduction. We encountered haemolysis in a series of leucofiltered units. This stressed our precious inventory, added to financial loss, increased our turn-around time to issue leucofiltered blood units, and placed doubts on the safety of our leucofiltered products. A systematic root cause analysis was done to identify the reason for haemolysis.
Materials and Methods: A total of 69 units were leucofiltered during the study period, of which 13 units showed lysis following filtration.
Results: This study warranted a review of our existing leucofiltration standard operating procedures to keep strict adherence to manufacturer instructions to ensure quality in the end product.
Conclusions: Among the leucofiltered units showing hemolysis, 62% were due to higher temperature, 23% due to increased time for filtration, and 15% due to increased holding time of red cell units.
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Type of Study: Research | Subject: Hematology & Blood Banking
Received: 2021/08/17 | Accepted: 2021/11/17 | Published: 2021/03/29

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