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International Journal of Medical Laboratory
Shahid Sadoughi University of Medical Sciences
Wed, Nov 12, 2025
[Archive]
Alireza Daneshvar 
, Mostafa Teymuri Kheravi * , Mehdi Mohsenzadeh , Najmeh-Alsadat Shojaeian , Bahram Abedi
, Mostafa Teymuri Kheravi * , Mehdi Mohsenzadeh , Najmeh-Alsadat Shojaeian , Bahram Abedi
Department of Sports Sciences, Boj.C., Islamic Azad University, Bojnord, Iran
Abstract: (14 Views)
Introduction: Sports training has been shown to have a positive impact on conditions such as dementia, but its exact mechanisms remain unclear. The present study aimed to determine the effects of pre-training with endurance and cognitive endurance training on brain-derived neurotrophic factor levels in aged rats after dementia.
Materials and Methods: Male Wistar rats were randomly divided into 4 groups of 10. These groups included the healthy control group, the dementia group, the dementia group with endurance training, and the dementia group with cognitive-endurance training. Trihexyphenidyl was used to create a mouse model of dementia. Swimming and the Morris water maze were considered for endurance and cognitive endurance training, respectively. After the training period, the expression level of brain-derived neurotrophic factor was measured using the Real-Time polymerase chain reaction.
Results: Brain-derived neurotrophic factor expression is significantly decreased in rats with dementia compared to control rats. Exercise had a positive effect on brain-derived neurotrophic factor expression (p<0.05). Cognitive- endurance exercise was found to be more effective than endurance exercise.
Conclusion: Endurance and cognitive-endurance exercises can be considered suitable strategies for preventing dementia in the elderly and also for reducing the complications of dementia in affected people.
Materials and Methods: Male Wistar rats were randomly divided into 4 groups of 10. These groups included the healthy control group, the dementia group, the dementia group with endurance training, and the dementia group with cognitive-endurance training. Trihexyphenidyl was used to create a mouse model of dementia. Swimming and the Morris water maze were considered for endurance and cognitive endurance training, respectively. After the training period, the expression level of brain-derived neurotrophic factor was measured using the Real-Time polymerase chain reaction.
Results: Brain-derived neurotrophic factor expression is significantly decreased in rats with dementia compared to control rats. Exercise had a positive effect on brain-derived neurotrophic factor expression (p<0.05). Cognitive- endurance exercise was found to be more effective than endurance exercise.
Conclusion: Endurance and cognitive-endurance exercises can be considered suitable strategies for preventing dementia in the elderly and also for reducing the complications of dementia in affected people.
Keywords: Brain-derived neurotrophic factor, Cognitive-endurance exercise, Dementia, Endurance exercise, Exercise
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