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International Journal of Medical Laboratory
Shahid Sadoughi University of Medical Sciences
Sun, Sep 28, 2025
[Archive]
Department of Pathology, Shahid Sadoughi Hospital, Shool of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract: (21 Views)
Introduction: Signet-ring cell carcinoma (SRCC) is a highly aggressive subtype of adenocarcinoma distinguished by the presence of mucin-secreting signet-ring cells. Although SRCC is rare, it is often diagnosed at advanced stages and has a poor prognosis. Knowing the clinical symptoms of SRCC can help with early diagnosis and better management of the patients. This article aims to determine the characteristics, anatomical sites involved, clinical symptoms, and survival times of patients with SRCC.
Materials and Methods: We retrospectively studied clinical records of patients diagnosed with SRCC from 2011 to 2021 in the Pathology Department of Shahid Sadoughi Hospital. We obtained the survival duration by contacting the patients. Age, sex, anatomical position of the carcinoma, and clinical symptoms of patients were identified.
Results:143 eligible SRCC patients were enrolled, including 77 men and 66 women. The mean age of the population was 55.15±16.29 years. Regarding the anatomical position of carcinoma, the highest percentage of involvement was in the stomach (67.8%), followed by the esophagus (9.1%) and lung (7.7%). The most frequent clinical symptom was abdominal pain (36.3%), followed by dyspepsia (16.8%) and Gastrointestinal obstruction (14%). Among the 57 patients for whom survival data were available, the median survival duration was 7 months. The survival rates after 1, 3, and 5 years were 40%, 32% and 24%, respectively.
Conclusion: The clinicopathological characteristics and survival time of SRCC patients were determined and reported. The stomach was the most frequently involved organ, and abdominal pain was the most reported clinical symptom.
Materials and Methods: We retrospectively studied clinical records of patients diagnosed with SRCC from 2011 to 2021 in the Pathology Department of Shahid Sadoughi Hospital. We obtained the survival duration by contacting the patients. Age, sex, anatomical position of the carcinoma, and clinical symptoms of patients were identified.
Results:143 eligible SRCC patients were enrolled, including 77 men and 66 women. The mean age of the population was 55.15±16.29 years. Regarding the anatomical position of carcinoma, the highest percentage of involvement was in the stomach (67.8%), followed by the esophagus (9.1%) and lung (7.7%). The most frequent clinical symptom was abdominal pain (36.3%), followed by dyspepsia (16.8%) and Gastrointestinal obstruction (14%). Among the 57 patients for whom survival data were available, the median survival duration was 7 months. The survival rates after 1, 3, and 5 years were 40%, 32% and 24%, respectively.
Conclusion: The clinicopathological characteristics and survival time of SRCC patients were determined and reported. The stomach was the most frequently involved organ, and abdominal pain was the most reported clinical symptom.
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