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International Journal of Medical Laboratory
Shahid Sadoughi University of Medical Sciences
Thu, Oct 30, 2025
[Archive]
Department of Pathology, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract: (35 Views)
Introduction: Platelets play a crucial role in maintaining endothelial integrity and controlling bleeding in small vascular injuries by forming platelet plugs. Thrombocytopenia encompasses a wide range of clinical manifestations and pathological diagnoses. This study aimed to evaluate the clinicopathological features of thrombocytopenia in children under 14 years presenting to Shahid Sadoughi Hospital, Yazd.
Materials and Methods: Data were collected using a pre-designed checklist including age, gender, pathological diagnosis, complete blood count (CBC) findings, and clinical symptoms. All cases of thrombocytopenia in children under 14 years were extracted from the pathology records of Shahid Sadoughi Hospital. The data were analyzed using SPSS software, employing the Chi-square test. A p-value < 0.05 was considered statistically significant.
Results: Bone marrow aspirations from 375 children under 14 years with thrombocytopenia were analyzed, including 215 males and 160 females. The most affected age group was 1–5 years (50.7%), with males comprising 57.3% of cases. The most common pathological finding was acute leukemia (47.2%). Non-malignant diagnoses were overall more prevalent than malignant ones. The most frequent CBC finding was bicytopenia (low platelets and hemoglobin, 44.8%), and the most common clinical manifestation was bleeding manifestations (48.3%).
Conclusion: This study highlights that acute leukemia is the predominant pathological diagnosis in pediatric thrombocytopenia, with bleeding manifestations being the most common clinical presentation. These findings underscore the importance of thorough clinicopathological evaluation in effectively managing pediatric thrombocytopenia.
Materials and Methods: Data were collected using a pre-designed checklist including age, gender, pathological diagnosis, complete blood count (CBC) findings, and clinical symptoms. All cases of thrombocytopenia in children under 14 years were extracted from the pathology records of Shahid Sadoughi Hospital. The data were analyzed using SPSS software, employing the Chi-square test. A p-value < 0.05 was considered statistically significant.
Results: Bone marrow aspirations from 375 children under 14 years with thrombocytopenia were analyzed, including 215 males and 160 females. The most affected age group was 1–5 years (50.7%), with males comprising 57.3% of cases. The most common pathological finding was acute leukemia (47.2%). Non-malignant diagnoses were overall more prevalent than malignant ones. The most frequent CBC finding was bicytopenia (low platelets and hemoglobin, 44.8%), and the most common clinical manifestation was bleeding manifestations (48.3%).
Conclusion: This study highlights that acute leukemia is the predominant pathological diagnosis in pediatric thrombocytopenia, with bleeding manifestations being the most common clinical presentation. These findings underscore the importance of thorough clinicopathological evaluation in effectively managing pediatric thrombocytopenia.
Keywords: Acute leukemia, Bone marrow aspiration, Clinicopathological evaluation, Cytopenia, Pediatrics, Thrombocytopenia
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