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International Journal of Medical Laboratory
Shahid Sadoughi University of Medical Sciences
Sat, Nov 23, 2024
[Archive]
Volume 3, Issue 1 (February 2016)
IJML 2016, 3(1): 13-19 |
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Jebali A, Kazemi B, Hekmatimoghaddam S. Quantification of Human Chorionic Gonadotropin by Bovine Serum Albumin Nanoparticles. IJML 2016; 3 (1) :13-19
URL: http://ijml.ssu.ac.ir/article-1-84-en.html
URL: http://ijml.ssu.ac.ir/article-1-84-en.html
Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract: (2101 Views)
Background and Aims: Some nanoparticles can be used in immunoassays to increase sensitivity. This study aimed to evaluate a novel nano-immunoassay based on bovine serum albumin nanoparticles (BSA NPs).
Materials and methods: At first, the nanostructure was synthesized, and then applied as a tag in the nano-immunoassay. Then the concentration of β-subunit of human chorionic gonadotropin (βHCG) in the clinical samples was quantified by traditional enzyme-linked immunosorbent assay (ELISA), and then checked by the nano-immunoassay.
Results: The Pearson’s correlation coefficient between ELISA and nano-immunoassay was high, i.e., 0.80. Relative sensitivity and specificity of this nano-immunoassay were reported 97.4% and 96.6%, respectively.
Conclusions: BSA NPs can be applied in nano-immunoassays as a new structure, and as an example, βHCG can be detected by this novel assay.
Type of Study: Research |
Subject:
Genetics/ Biotechnology
Received: 2016/03/9 | Accepted: 2016/03/9 | Published: 2016/03/9
Received: 2016/03/9 | Accepted: 2016/03/9 | Published: 2016/03/9
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