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International Journal of Medical Laboratory
Shahid Sadoughi University of Medical Sciences
Wed, Nov 27, 2024
[Archive]
Volume 3, Issue 1 (February 2016)
IJML 2016, 3(1): 43-49 |
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Aliabadi A, Izadi M, Rezvani M E, Esmaeili-dehaj M. Effects of Thymol on Serum Biochemical and Antioxidant Indices in Kindled Rats. IJML 2016; 3 (1) :43-49
URL: http://ijml.ssu.ac.ir/article-1-91-en.html
URL: http://ijml.ssu.ac.ir/article-1-91-en.html
Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract: (2258 Views)
Background and Aims: Kindling is regarded as an experimental model of temporal lobe epilepsy that reflects a process of progressive and persistent intensification of seizure. Experimental and clinical evidence suggest that there is an interrelationship among epileptogenesis, local inflammation and antioxidant activity. In this study, the possible antioxidant and anti-inflammatory effects of thymol was investigated in epileptic rats.
Materials and Methods: Kindling was induced by repeated injections of intraperitoneal pentylenetetrazole (PTZ) every other day. Then, the rat hippocampi were isolated, weighed and prepared as a 5% tissue homogenate in ice-cold 0.9% saline solution. Serum malondialdehyde (MDA) and superoxide dismutase (SOD) levels were assessed by thiobarbituric acid reacting substance and nitroblue tetrazolium methods respectively. Hyppocampal tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) were evaluated using enzyme-linked immunosorbent assay method.
Results: As the study findings revealed, epileptic seizures increase the serum level of MDA, hyppocampal levels of TNF-α as well as IL-1β and decrease the SOD activity.
Conclusions: thymol exerts anticonvulsant activity through the antioxidant and anti-inflammatory mechanisms.
Type of Study: Research |
Subject:
General
Received: 2016/03/15 | Accepted: 2016/03/15 | Published: 2016/03/15
Received: 2016/03/15 | Accepted: 2016/03/15 | Published: 2016/03/15
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