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International Journal of Medical Laboratory
Shahid Sadoughi University of Medical Sciences
Fri, Oct 24, 2025
[Archive]
Volume 5, Issue 4 (November 2018)
IJML 2018, 5(4): 288-293 |
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Moinzadeh L, Keramati M R, Jalali M T, Keikhaei B, Saki N, Saki Malehi A, et al . Survey of the Status of Iron and Sclerostin in Major Thalassemia Patients . IJML 2018; 5 (4) :288-293
URL: http://ijml.ssu.ac.ir/article-1-200-en.html
URL: http://ijml.ssu.ac.ir/article-1-200-en.html
Leila Moinzadeh 
, Mohammad Reza Keramati , Mohammad Taha Jalali , Bejan Keikhaei , Najmaldin Saki , Amal Saki Malehi , Zahra Mohammadi , Mohammad Mirdoraghi , Seyyede Fatemeh Shams , Mohammad Hadi Sadeghian *
, Mohammad Reza Keramati , Mohammad Taha Jalali , Bejan Keikhaei , Najmaldin Saki , Amal Saki Malehi , Zahra Mohammadi , Mohammad Mirdoraghi , Seyyede Fatemeh Shams , Mohammad Hadi Sadeghian *
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract: (2395 Views)
Background and Aims: Thalassemia is one the most prevalent genetic anemia in the world; homozygote patients usually suffer from severe disturbances. Osteopenia and osteoporosis are of various types of thalassemia complications which increase in rate in patients with iron overload conditions. Sclerostin is a protein which enhances bone loss by inhibiting osteoblasts. The aim of this study was to measure sclerostin protein and its association with iron overload in major thalassemia patients.
Materials and Methods: Forty patients with major beta-Thalassemia and 40 healthy control individuals were includedin the study; Sclerostin protein and ferritin were evaluated using enzyme-linked immunosorbent assay method.
Results: Mean sclerostin protein was 100.7 pg/ml, in the case group; it was 143.1 pg/ml in the control group.There was a significant differences between sclerostin protein in case and control groups (p= 0.01). The association of sclerostin and ferritin was not significant in the case group (p= 0.7), while it was meaningful in the control individuals (p= 0.04).
Conclusions: Our findings suggest that sclerostin protein can play an important role in the pathogenesis of osteoporosis.
Materials and Methods: Forty patients with major beta-Thalassemia and 40 healthy control individuals were includedin the study; Sclerostin protein and ferritin were evaluated using enzyme-linked immunosorbent assay method.
Results: Mean sclerostin protein was 100.7 pg/ml, in the case group; it was 143.1 pg/ml in the control group.There was a significant differences between sclerostin protein in case and control groups (p= 0.01). The association of sclerostin and ferritin was not significant in the case group (p= 0.7), while it was meaningful in the control individuals (p= 0.04).
Conclusions: Our findings suggest that sclerostin protein can play an important role in the pathogenesis of osteoporosis.
Type of Study: Research |
Subject:
Hematology & Blood Banking
Received: 2017/09/21 | Accepted: 2018/09/26 | Published: 2018/11/15
Received: 2017/09/21 | Accepted: 2018/09/26 | Published: 2018/11/15
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