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Volume 5, Issue 3 (August 2018)                   IJML 2018, 5(3): 208-213 | Back to browse issues page

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Faramarzi A, Safaralizadeh R, Hosseinpourfeizi M, Moaddab Y. Evaluation of MLL2 (KMT2B) Gene Expression in Colorectal Cancer Tissue Compared with Adjacent Tumor Free Tissue. IJML. 2018; 5 (3) :208-213
URL: http://ijml.ssu.ac.ir/article-1-213-en.html
Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Abstract:   (1201 Views)
Background and Aims: An impairment of expression in MLL2 gene involved in histone methylation induces alteration in the methylation patterns at enhancers and causes several cancers including colon cancer. In this study, MLL2 expression was evaluated in North West of Iran.
Materials and Methods: To evaluate the MLL2 expression in patients with colon cancer, 25 tumor samples and 25 samples of tumor margins were collected and analyzed by real-time polymerase chain reaction.
Results: KMT2B level was not associated with age (p=0.3), gender (p=0.05) and tumor size (p=0.2) but had relation with stage of tumor (p=0.04).
Conclusions: According to the results obtained from investigating
the MLL2 gene expression, it was found that it has a significant relationship with the stage of tumor.
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Type of Study: Research | Subject: Genetics/ Biotechnology
Received: 2018/01/11 | Accepted: 2018/07/15 | Published: 2018/08/15

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