International Journal of Medical Laboratory

D-dimer is an essential biomarker for thrombotic disorders. Recent studies have developed aptamer-based lateral flow immunoassays (LFIAs) to detect D-dimer rapidly. This advanced platform merges the specificity of aptamers with lateral flow technology, enabling convenient point-of-care testing. Through optimization, assays have demonstrated high sensitivity and selectivity for D-dimer detection in clinical samples, making the platform a reliable marker for thrombosis. The platform offers a practical point-of-care diagnostic solution for thrombosis, with advantages such as rapid turnaround times, ease of use, and cost-effectiveness. Herein, this literature survey tries to discuss and underscore the effectiveness of aptamer-based LFIA as an innovative method for a rapid detection of D-dimer.